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Human islet isolation and allotransplantation in 22 consecutive cases

Ricordi, C and Tzakis, AG and Carroll, PB and Zeng, Y and Rodriguez Rilo, HL and Alejandro, R and Shapiro, R and Fung, JJ and Demetris, AJ and Mintz, DH and Starzl, TE (1992) Human islet isolation and allotransplantation in 22 consecutive cases. Transplantation, 53 (2). 407 - 414. ISSN 0041-1337

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Abstract

This report provides our initial experience in islet isolation and intrahepatic allotransplantation in 21 patients. In group 1, 10 patients underwent combined liver-islet allotransplantation following upper-abdominal exenteration for cancer. In group 2, 4 patients received a combined liver-islet allograft for cirrhosis and diabetes. One patient had plasma C-peptide > 3 pM and was therefore excluded from analysis. In group 3, 7 patients received 8 combined cadaveric kidney-islet grafts (one retransplant) for end-stage renal disease secondary to type 1 diabetes mellitus. The islets were separated by a modification of the automated method for human islet isolation and the preparations were infused into the portal vein. Immunosuppression was with FK506 (group 1) plus steroids (groups 2 and 3). Six patients in group 1 did not require insulin treatment for 5 to > 16 months. In groups 2 and 3 none of the patients became insulin-independent, although decreased insulin requirement and stabilization of diabetes were observed. Our results indicate that rejection is still a major factor limiting the clinical application of islet transplantation in patients with type 1 diabetes mellitus, although other factors such as steroid treatment may contribute to deteriorate islet engraftment and/or function. © 1992 by Williams and Wilkins.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Ricordi, C
Tzakis, AG
Carroll, PB
Zeng, Y
Rodriguez Rilo, HL
Alejandro, R
Shapiro, R
Fung, JJ
Demetris, AJ
Mintz, DH
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1992
Date Type: Publication
Journal or Publication Title: Transplantation
Volume: 53
Number: 2
Page Range: 407 - 414
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1337
Other ID: uls-drl:31735062111350, Starzl CV No. 1340
Date Deposited: 08 Apr 2010 17:22
Last Modified: 13 Oct 2017 21:57
URI: http://d-scholarship.pitt.edu/id/eprint/4726

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