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Pretransplant assessment of human liver grafts by plasma lecithin: cholesterol acyltransferase (LCAT) activity in multiple organ donors.

Shimada, M and Yanaga, K and Higashi, H and Makowka, L and Kakizoe, S and Starzl, TE (1992) Pretransplant assessment of human liver grafts by plasma lecithin: cholesterol acyltransferase (LCAT) activity in multiple organ donors. Transpl Int, 5 (1). 27 - 30. ISSN 0934-0874

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Abstract

In spite of the improved outcome of orthotopic liver transplantation (OLTx), primary graft nonfunction remains one of the life-threatening problems following OLTx. The purpose of this study was to evaluate plasma lecithin: cholesterol acyltransferase (LCAT) activity in multiple organ donors as a predictor of liver allograft viability prior to OLTx. Thirty-nine donors were studied during a 5-month period between April and August 1988. Allograft hepatectomy was performed using a rapid technique or its minor modification with hilar dissections, and the allografts were stored cold (4 degrees C) in University of Wisconsin (UW) solution. Early post-transplant allograft function was classified as good, fair, or poor, according to the highest SGOT, SGPT, and prothrombin time within 5 days following OLTx. Procurement records were reviewed to identify donor data, which included conventional liver function tests, duration of hospital stay, history of cardiac arrest, and graft ischemic time. Blood samples from the donors were drawn immediately prior to aortic crossclamp, and from these plasma LCAT activity was determined. Plasma LCAT activity of all donors was significantly lower than that of healthy controls (12.4 +/- 8.0 vs 39.2 +/- 13.3 micrograms/ml per hour, P less than 0.01). LCAT activity (16.4 +/- 8.3 micrograms/ml per hour) in donors of grafts with good function was significantly higher than that in those with fair (8.6 +/- 4.5 micrograms/ml per hour, P less than 0.01) or poor (7.3 +/- 2.4 micrograms/ml per hour, P less than 0.01) function.(ABSTRACT TRUNCATED AT 250 WORDS)


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Shimada, M
Yanaga, K
Higashi, H
Makowka, L
Kakizoe, S
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: March 1992
Date Type: Publication
Journal or Publication Title: Transpl Int
Volume: 5
Number: 1
Page Range: 27 - 30
Institution: University of Pittsburgh
Refereed: Yes
Uncontrolled Keywords: Adolescent, Adult, Child, Female, Graft Survival, Humans, Liver Transplantation, Male, Phosphatidylcholine-Sterol O-Acyltransferase, Prognosis, Tissue Donors
ISSN: 0934-0874
Funders: NIDDK NIH HHS (R01 DK029961-19)
Other ID: uls-drl:31735062111533, Starzl CV No. 1364
Date Deposited: 08 Apr 2010 17:23
Last Modified: 05 Dec 2017 16:59
URI: http://d-scholarship.pitt.edu/id/eprint/4750

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