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Conversion of liver allograft recipients from cyclosporine to FK506 immunosuppressive therapy— a clinicopathologic study of 96 patients

Demetris, AJ and Fung, JJ and Todo, S and McCauley, J and Jain, A and Takaya, S and Alessiani, M and Abu-Elmagd, K and Van Thiel, DH and Starzl, TE (1992) Conversion of liver allograft recipients from cyclosporine to FK506 immunosuppressive therapy— a clinicopathologic study of 96 patients. Transplantation, 53 (5). 1056 - 1062. ISSN 0041-1337

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Abstract

The effect of conversion from cyclosporine-steroid immunosuppression to the new agent FK506 was studied in 96 liver allograft recipients who were experiencing graft dysfunction or cyclosporine toxicity. Patients were stratified according to the cause of graft dysfunction that ultimately led to conversion to FK506. Response to FK506 introduction was monitored pathologically and biochemically. The outcome of a switch from CsA to FK506 was highly favorable in patients experiencing acute and the early stages of chronic rejection, despite optimal conventional therapy. Patients with later stages of chronic rejection did not respond to conversion to FK506 and most eventually lost their liver grafts in this process. Patients in whom we had difficulty separating chronic rejection from chronic persistent or low-grade chronic active hepatitis were mostly unaffected by conversion to FK506. Active hepatitis was a poor indication for conversion, because most of the patients experienced graft failure or died from liver failure. As a group, there was no statistically significant change in renal function 180 days after conversion to FK506. These findings expand the experience with FK506 in human liver allograft recipients. © 1992 by Williams and Wilkins.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Demetris, AJ
Fung, JJ
Todo, S
McCauley, J
Jain, A
Takaya, S
Alessiani, M
Abu-Elmagd, K
Van Thiel, DH
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1992
Date Type: Publication
Journal or Publication Title: Transplantation
Volume: 53
Number: 5
Page Range: 1056 - 1062
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1337
Other ID: uls-drl:31735062111574, Starzl CV No. 1368
Date Deposited: 08 Apr 2010 17:23
Last Modified: 13 Oct 2017 22:55
URI: http://d-scholarship.pitt.edu/id/eprint/4754

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