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Improvement in Cognitive Functioning of Alcoholics Following Orthotopic Liver Transplantation

Arria, AM and Tarter, RE and Starzl, TE and Thiel, DHV (1991) Improvement in Cognitive Functioning of Alcoholics Following Orthotopic Liver Transplantation. Alcoholism: Clinical and Experimental Research, 15 (6). 956 - 962. ISSN 0145-6008

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Cognitive functioning in alcoholic cirrhotics before and 1 year following orthotopic liver transplantation was compared with age‐ and sex‐matched normal subjects. The alcoholic group improved significantly following transplantation on tests measuring psychomotor, visuo‐practic and abstracting abilities whereas the performance of normal controls remained virtually unchanged. In contrast, memory capacity in alcoholics with cirrhosis did not statistically improve following successful transplantation. Further investigation, using more sophisticated measures of memory function, are required to determine whether memory deficits are either associated with alcohol neuro‐toxicity or an irreversible component of hepatic encephalopathy. These findings suggest that a reversible hepatic encephalopathy underlies many of the neuropsychologic deficits observed in cirrhotic alcoholics and can be ameliorated following successful liver transplantation. Copyright © 1991, Wiley Blackwell. All rights reserved


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Arria, AM
Tarter, REtarter@pitt.eduTARTER
Starzl, TEtes11@pitt.eduTES11
Thiel, DHV
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1991
Date Type: Publication
Journal or Publication Title: Alcoholism: Clinical and Experimental Research
Volume: 15
Number: 6
Page Range: 956 - 962
DOI or Unique Handle: 10.1111/j.1530-0277.1991.tb05195.x
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0145-6008
Other ID: uls-drl:, Starzl CV No. 1371
Date Deposited: 08 Apr 2010 17:23
Last Modified: 02 Feb 2019 13:57


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