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Adenovirus infection in pediatric liver transplant recipients

Michaels, MG and Green, M and Wald, ER and Starzl, TE (1992) Adenovirus infection in pediatric liver transplant recipients. Journal of Infectious Diseases, 165 (1). 170 - 174. ISSN 0022-1899

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A retrospective review of adenoviral infection in pediatric liver transplant recipients was done at Children’s Hospital of Pittsburgh to define its epidemiology and clinical importance. Medical records of patients with adenovirus were reviewed and data collected regarding clinical course, microbiologic studies, biopsy results, immunosuppression, concurrent infections, and outcome. Of 484 liver transplant recipients, 49 had 53 episodes of adenoviral infection. The most common sites of adenoviral infection were the liver, lung, and gastrointestinal tract. Serotypes 1, 2, and 5 were recovered most often; type 5 was commonly associated with hepatitis. Invasive adenoviral infection occurred in 20 children, leading to death in 9. Median time from transplantation until isolation of adenovirus was 25.5 days. This timing suggests either reactivation or donor-associated transmission. Prospective studies using molecular epidemiologic techniques will be helpful in evaluating transmission patterns of adenovirus in this population. © 1992 Oxford University Press.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Michaels, MG
Green, Mgreenm@pitt.eduGREENM
Wald, ER
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1992
Date Type: Publication
Journal or Publication Title: Journal of Infectious Diseases
Volume: 165
Number: 1
Page Range: 170 - 174
DOI or Unique Handle: 10.1093/infdis/165.1.170
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0022-1899
Other ID: uls-drl:31735062111624, Starzl CV No. 1372
Date Deposited: 08 Apr 2010 17:23
Last Modified: 05 Feb 2019 07:55


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