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Detection of intrahepatic human islets following combined liver-islet allotransplantation

Ricordi, C and Tzakis, A and Alejandro, R and Zeng, Y and Demetris, AJ and Carroll, P and Fung, JJ and Mintz, DH and Starzl, TE (1992) Detection of intrahepatic human islets following combined liver-islet allotransplantation. Pancreas, 7 (4). 507 - 509. ISSN 0885-3177

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This article describes the localization of intact insulin-containing intrahepatic islets after combined liver-islet allotransplantation. The patient was a 36-year-old woman who underwent upper abdominal exenteration for neuroendocrine carcinoma; 289,000 islets were transplanted via portal vein infusion immediately after complete revascularization of the liver. Immunosuppression was with low-dose FK-506. OKT3 and steroids were used to treat one rejection episode 2 weeks after transplantation, but the patient subsequently developed multiple infections and died 109 days after transplantation. At autopsy, the transplanted liver did not show any sign of rejection and well-preserved islets were present in portal triads sampled from the anterior inferior edge of the right lobe. Immunohistochemical labeling confirmed the presence of insulin-containing cells. This finding indicated that human islets can survive after intrahepatic allotransplantation, despite positive cross-match with no HLA antigen match, suggesting that upper abdominal exenteration and liver transplantation may constitute a protective factor for the survival of allogeneic human islets. © 1992 Raven Press, Ltd., New York.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Ricordi, C
Tzakis, A
Alejandro, R
Zeng, Y
Demetris, AJ
Carroll, P
Fung, JJ
Mintz, DH
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1992
Date Type: Publication
Journal or Publication Title: Pancreas
Volume: 7
Number: 4
Page Range: 507 - 509
DOI or Unique Handle: 10.1097/00006676-199207000-00014
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0885-3177
Other ID: uls-drl:31735062111616, Starzl CV No. 1373
Date Deposited: 08 Apr 2010 17:23
Last Modified: 27 Jan 2019 02:55


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