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Total hepatectomy and liver transplant for hepatocellular adenomatosis and focal nodular hyperplasia.

Marino, IR and Scantlebury, VP and Bronsther, O and Iwatsuki, S and Starzl, TE (1992) Total hepatectomy and liver transplant for hepatocellular adenomatosis and focal nodular hyperplasia. Transplant international : official journal of the European Society for Organ Transplantation, 5 Supp. ISSN 0934-0874

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Abstract

Extensive hepatocellular adenomatosis (HA) and focal nodular hyperplasia (FNH) represent a proliferation of hepatic cells that occurs most frequently in women. These lesions are uncommon in the pediatric age group, accounting for 2% of pediatric hepatic tumors, and are extremely rare in males. The etiology of HA and FNH has been correlated with the use of oral contraceptives. We report to the best of our knowledge the first series of patients treated with OLTx for HA and FNH (five cases). All these patients had lesions involving at least 90% of the hepatic parenchyma and all underwent major hepatic surgery before OLTx because of life threatening complications. One patient died in the immediate postoperative period following retransplantation for primary non-function of the first OLTx. Four out of five patients are currently alive from 4.1 to 9.6 years after OLTx. Our results justify the use of OLTx for symptomatic patients with HA and FNH who cannot be treated with conventional hepatic resections.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Marino, IR
Scantlebury, VP
Bronsther, O
Iwatsuki, S
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1992
Date Type: Publication
Journal or Publication Title: Transplant international : official journal of the European Society for Organ Transplantation
Volume: 5 Supp
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0934-0874
Other ID: uls-drl:31735062111665, Starzl CV No. 1376
Date Deposited: 08 Apr 2010 17:23
Last Modified: 16 Feb 2019 13:55
URI: http://d-scholarship.pitt.edu/id/eprint/4762

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