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Incidence, prevalence, and clinical course of hepatitis C following liver transplantation

Shah, G and Demetris, AJ and Gavaler, JS and Lewis, JH and Todo, S and Starzl, TE and Van Thiel, DH (1992) Incidence, prevalence, and clinical course of hepatitis C following liver transplantation. Gastroenterology, 103 (1). 323 - 329. ISSN 0016-5085

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Hepatitis C virus (HCV) is the agent responsible for posttransfusion hepatitis. The incidence, timing, and clinical course of HCV positive hepatitis in liver transplant recipients are unknown. Three hundred and seventeen donor-recipient liver transplant pairs were grouped on the basis of their pretransplant HCV antibody status. The biopsy findings were examined. Four distinct groups were identified on the basis of HCV serology: group I, both were negative; group II, donor was negative and recipient was positive; group III, donor was positive and recipient was negative; group IV, both were positive. The prevalence of anti-HCV positivity in recipients was 13.6%. The rate of seroconversion was 9.2%. Histologic hepatitis not ascribable to any specific cause other than non-A, non-B (NANB) hepatitis occurred in 13.8%. The incidence of histologic chronic active hepatitis was 1.6%, and none progressed to cirrhosis. The concordance rate for a positive anti-HCV serology and NANB hepatitis was 2.8%. Of the 35 patients (group II and IV) with positive anti-HCV serology pretransplant, only 17 were positive posttransplantation. Based on these data it can be concluded that posttransplant NANB hepatitis occurred in 13.8% of liver recipients. Twenty percent of these were anti-HCV positive. Progression to histologic chronic active hepatitis occurs over a period of 1-5 years in 1.6% of cases. © 1992.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Shah, G
Demetris, AJ
Gavaler, JS
Lewis, JH
Todo, S
Starzl, TEtes11@pitt.eduTES11
Van Thiel, DH
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1992
Date Type: Publication
Journal or Publication Title: Gastroenterology
Volume: 103
Number: 1
Page Range: 323 - 329
DOI or Unique Handle: 10.1016/0016-5085(92)91130-v
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0016-5085
Other ID: uls-drl:31735062111657, Starzl CV No. 1377
Date Deposited: 08 Apr 2010 17:23
Last Modified: 27 Jan 2019 02:55


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