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Liver Transplantation for Alagille's Syndrome

Tzakis, AG and Reyes, J and Tepetes, K and Tzoracoleftherakis, V and Todo, S and Starzl, TE (1993) Liver Transplantation for Alagille's Syndrome. Archives of Surgery, 128 (3). 337 - 339. ISSN 0004-0010

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Abstract

Twenty-three children with Alagille's syndrome and end-stage liver disease underwent liver transplantation with cyclosporine and low-dose steroid immunosuppression. Two to 9 years (mean, 4.4 years) after surgery, 13 (57%) of the children were still alive, with normal liver function. Three of the fatalities were due to cardiovascular failure secondary to associated cardiopulmonary disease. Mortality was higher among patients who had more severe cardiac disease and patients who had previously undergone a Kasai procedure. Although it has a higher than average risk, liver transplantation can be efficacious in patients with Alagille's syndrome and end-stage liver disease. (Arch Surg. 1993;128:337-339). © 1993, American Medical Association. All rights reserved.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Tzakis, AG
Reyes, J
Tepetes, K
Tzoracoleftherakis, V
Todo, S
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1993
Date Type: Publication
Journal or Publication Title: Archives of Surgery
Volume: 128
Number: 3
Page Range: 337 - 339
DOI or Unique Handle: 10.1001/archsurg.1993.01420150093017
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0004-0010
Other ID: uls-drl:31735062111905, Starzl CV No. 1400
Date Deposited: 08 Apr 2010 17:23
Last Modified: 02 Feb 2019 13:56
URI: http://d-scholarship.pitt.edu/id/eprint/4786

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