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The effect of prednisone on pancreatic islet autografts in dogs

Zeng, Y and Ricordi, C and Lendoire, J and Carroll, PB and Alejandro, R and Bereiter, DR and Tzakis, A and Starzl, TE (1993) The effect of prednisone on pancreatic islet autografts in dogs. Surgery, 113 (1). 98 - 102. ISSN 0039-6060

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Abstract

Prednisone was shown to induce hyperglycemia in dogs submitted to total pancreatectomy and pancreatic islet autotransplantation. The hyperglycemia caused by a 10-day course of prednisone, 1 mg/kg/day, starting on the day of operation was reversible within 1 week after steroid discontinuance. Three weeks after prednisone was stopped, there was no detectable adverse effect on glucose homeostasis as judged by fasting blood sugar levels and intravenous glucose tolerance test results. Four months after transplantation, glucose disappearance was delayed in animals previously treated with the prednisone compared with those previously treated with prednisone plus insulin or control animals. This was accompanied by lower insulin values on intravenous glucose tolerance testing and suggests a long-term subtle effect on islet function. The mechanism of the steroid effect is not known. However, this model could be used to test the diabetogenicity of other immunosuppressive agents including cyclosporine, FK 506, and azathioprine. © 1993.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Zeng, Y
Ricordi, C
Lendoire, J
Carroll, PB
Alejandro, R
Bereiter, DR
Tzakis, A
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1993
Date Type: Publication
Journal or Publication Title: Surgery
Volume: 113
Number: 1
Page Range: 98 - 102
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0039-6060
Other ID: uls-drl:31735062112093, Starzl CV No. 1421
Date Deposited: 08 Apr 2010 17:24
Last Modified: 13 Oct 2017 21:56
URI: http://d-scholarship.pitt.edu/id/eprint/4807

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