Ricordi, C and Carroll, P and Tzakis, A and Zeng, Y and Rilo, HLR and Alejandro, R and Shapiro, R and Fung, JJ and Demetris, AJ and Mintz, DH and Starzl, TE
(1992)
Outcome of human islet isolation and allotransplantation in 20 consecutive cases.
Diabetes Nutr Metab, 5 Supp.
193 - 198.
ISSN 0394-3402
Abstract
This report provides our initial experience on islet isolation and intrahepatic allotransplantation in 20 patients. In Group 1, 10 patients underwent combined liver-islet allotransplantation following upper-abdominal exenteration for cancer. One patient underwent pancreatic islet allograft after near total pancreatectomy for chronic pancreatitis. In Group 2, 3 Type I diabetic patients received a combined liver-islet allograft for cirrhosis and diabetes. In Group 3, 7 Type I diabetic patients received 8 combined cadaveric kidney-islet grafts (one retransplant) for end stage renal disease. The islets were separated by a modification of the automated method for human islet isolation and the preparations were infused into the portal vein. Immunosuppression was with FK-506 (Group 1) plus steroids (Groups 2 and 3). Six patients in Group 1 did not require insulin treatment for 5 to >16 mo. In Groups 2 and 3 none of the patients became insulin-independent, although ongoing C-peptide secretion, decreased insulin requirement and stabilization of diabetes were observed. Our results indicate that islet transplantation is most effective in pancreatectomy induced diabetes. However, rejection is still a major factor limiting the clinical application of islet transplantation in patients with Type I diabetes mellitus. Other factors such as steroid treatment may contribute to deteriorate islet engraftment and/or function.
Share
Citation/Export: |
|
Social Networking: |
|
Details
Item Type: |
Article
|
Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID ![](/images/orcid_id_24x24.png) |
---|
Ricordi, C | | | | Carroll, P | | | | Tzakis, A | | | | Zeng, Y | | | | Rilo, HLR | | | | Alejandro, R | | | | Shapiro, R | | | | Fung, JJ | | | | Demetris, AJ | | | | Mintz, DH | | | | Starzl, TE | tes11@pitt.edu | TES11 | |
|
Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
Date: |
1992 |
Date Type: |
Publication |
Journal or Publication Title: |
Diabetes Nutr Metab |
Volume: |
5 Supp |
Page Range: |
193 - 198 |
Institution: |
University of Pittsburgh |
Refereed: |
Yes |
ISSN: |
0394-3402 |
Funders: |
NIDDK NIH HHS (R01 DK029961-19) |
Other ID: |
uls-drl:31735062112192, Starzl CV No. 1427 |
Date Deposited: |
08 Apr 2010 17:24 |
Last Modified: |
03 Jul 2024 12:55 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/4813 |
Metrics
Monthly Views for the past 3 years
Plum Analytics
Actions (login required)
![View Item View Item](/style/images/action_view.png) |
View Item |