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Outcome of human islet isolation and allotransplantation in 20 consecutive cases.

Ricordi, C and Carroll, P and Tzakis, A and Zeng, Y and Rilo, HLR and Alejandro, R and Shapiro, R and Fung, JJ and Demetris, AJ and Mintz, DH and Starzl, TE (1992) Outcome of human islet isolation and allotransplantation in 20 consecutive cases. Diabetes Nutr Metab, 5 Supp. 193 - 198. ISSN 0394-3402

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Abstract

This report provides our initial experience on islet isolation and intrahepatic allotransplantation in 20 patients. In Group 1, 10 patients underwent combined liver-islet allotransplantation following upper-abdominal exenteration for cancer. One patient underwent pancreatic islet allograft after near total pancreatectomy for chronic pancreatitis. In Group 2, 3 Type I diabetic patients received a combined liver-islet allograft for cirrhosis and diabetes. In Group 3, 7 Type I diabetic patients received 8 combined cadaveric kidney-islet grafts (one retransplant) for end stage renal disease. The islets were separated by a modification of the automated method for human islet isolation and the preparations were infused into the portal vein. Immunosuppression was with FK-506 (Group 1) plus steroids (Groups 2 and 3). Six patients in Group 1 did not require insulin treatment for 5 to >16 mo. In Groups 2 and 3 none of the patients became insulin-independent, although ongoing C-peptide secretion, decreased insulin requirement and stabilization of diabetes were observed. Our results indicate that islet transplantation is most effective in pancreatectomy induced diabetes. However, rejection is still a major factor limiting the clinical application of islet transplantation in patients with Type I diabetes mellitus. Other factors such as steroid treatment may contribute to deteriorate islet engraftment and/or function.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Ricordi, C
Carroll, P
Tzakis, A
Zeng, Y
Rilo, HLR
Alejandro, R
Shapiro, R
Fung, JJ
Demetris, AJ
Mintz, DH
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1992
Date Type: Publication
Journal or Publication Title: Diabetes Nutr Metab
Volume: 5 Supp
Page Range: 193 - 198
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0394-3402
Funders: NIDDK NIH HHS (R01 DK029961-19)
Other ID: uls-drl:31735062112192, Starzl CV No. 1427
Date Deposited: 08 Apr 2010 17:24
Last Modified: 18 Oct 2017 07:55
URI: http://d-scholarship.pitt.edu/id/eprint/4813

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