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Effect on the canine Eck fistula liver of intraportal TGF‐β alone or with hepatic growth factors

Francavilla, A and Azzarone, A and Carrieri, G and Scotti‐Fogueni, C and Zeng, Q‐ and Cillo, U and Porter, K and Starzl, TE (1992) Effect on the canine Eck fistula liver of intraportal TGF‐β alone or with hepatic growth factors. Hepatology, 16 (5). 1267 - 1270. ISSN 0270-9139

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Abstract

Transforming growth factor‐β canceled the hepatocyte proliferation caused by transforming growth factor‐α when the two substances were mixed and administered through a disconnected central portal vein branch after creation of an Eck fistula. In contrast, transforming growth factor‐β had no antidotal action on the stimulatory effects of insulin or full test doses of insulinlike factor‐2, hepatocyte growth factor, epidermal growth factor or triiodothymanine. A minor antidotal effect on hepatic stimulatory substance activity could be detected, but only with hepatic stimulatory substance was given in doses smaller than those known to cause maximum stimulatory response. These results suggest a highly specific pharmacological and physiological interaction between transforming growth factor‐α and transforming growth factor‐α in the modulation of liver growth control. (HEPATOLOGY 1992;16:1267–1270.) Copyright © 1992 American Association for the Study of Liver Diseases

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Francavilla, A
Azzarone, A
Carrieri, G
Scotti‐Fogueni, C
Zeng, Q‐
Cillo, U
Porter, K
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1992
Date Type: Publication
Journal or Publication Title: Hepatology
Volume: 16
Number: 5
Page Range: 1267 - 1270
DOI or Unique Handle: 10.1002/hep.1840160524
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0270-9139
Other ID: uls-drl:31735062112366, Starzl CV No. 1443
Date Deposited: 08 Apr 2010 17:24
Last Modified: 02 Aug 2020 10:59
URI: http://d-scholarship.pitt.edu/id/eprint/4829

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