Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Factors associated with invasive lung aspergillosis and the significance of positive aspergillus culture after liver transplantation

Kusne, S and Torre-Cisneros, J and Mañez, R and Irish, W and Martin, M and Fung, J and Simmons, RL and Starzl, TE (1992) Factors associated with invasive lung aspergillosis and the significance of positive aspergillus culture after liver transplantation. Journal of Infectious Diseases, 166 (6). 1379 - 1383. ISSN 0022-1899

[img]
Preview
PDF
Accepted Version
Available under License : See the attached license file.

Download (931kB) | Preview
[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)

Abstract

From January 1981 to December 1990, 2180 patients underwent orthotopic liver transplantation at the University of Pittsburgh. Thirty-two patients (1.5%) were identified with invasive aspergillosis (29 lung, 2 intraabdominal, 1 meningitis). Of 29 patients with invasive lung disease, only 23 (79%) had positive culture (Aspergillus fumigatus, 20; Aspergillus flavus, 3). Forty-eight variables were analyzed and compared in 23 patients with invasive disease with positive cultures and 9 patients with colonization only. The variables associated with pulmonary invasive disease, by univariate analysis, were surgical time (P =.03), presence of laparotomies (P =.02), higher creatinine level at time of Aspergillus isolation (P =.01), and use of OKT3 (P =.02). However, in a multivariate analysis, only the last two (creatinine, OKT3) were associated with invasive lung aspergillosis. Of 4 patients with positive abdominal wound culture, 2 had local invasive aspergillosis. Therefore, positive cultures of Aspergillus organisms from respiratory secretions and wound drainage may represent invasive disease and should not be ignored. © 1992 the University of Chicago.


Share

Citation/Export:
Social Networking:
Share |

Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Kusne, S
Torre-Cisneros, J
Mañez, R
Irish, W
Martin, M
Fung, J
Simmons, RL
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1992
Date Type: Publication
Journal or Publication Title: Journal of Infectious Diseases
Volume: 166
Number: 6
Page Range: 1379 - 1383
DOI or Unique Handle: 10.1093/infdis/166.6.1379
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0022-1899
Other ID: uls-drl:31735062112481, Starzl CV No. 1455
Date Deposited: 08 Apr 2010 17:24
Last Modified: 04 Feb 2019 15:58
URI: http://d-scholarship.pitt.edu/id/eprint/4841

Metrics

Monthly Views for the past 3 years

Plum Analytics

Altmetric.com


Actions (login required)

View Item View Item