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Randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone after renal transplantation: preliminary report.

Shapiro, R and Jordan, ML and Scantlebury, VP and Fung, JJ and Jensen, C and Vivas, C and McCauley, J and Irish, WD and Mitchell, S and Demetris, AJ (1993) Randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone after renal transplantation: preliminary report. Transplant Proc, 25 (1 Pt 1). 669 - 672. ISSN 0041-1345

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Abstract

FK 506 was used as a primary immunosuppressive agent in 125 cases of renal transplantation in a randomized trial comparing FK 506/prednisone with FK 506/azathioprine/prednisone. With a mean follow-up of 5.5 +/- 2.5 months, there has been a 6-month actuarial patient survival of 99% and graft survival of 88%. There is no difference thus far between the two-drug and three-drug groups, although there may be less rejection and diabetes in the three-drug group. These results suggest that FK 506 is a useful immunosuppressive agent in kidney transplantation.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Shapiro, R
Jordan, ML
Scantlebury, VP
Fung, JJ
Jensen, C
Vivas, C
McCauley, J
Irish, WD
Mitchell, S
Demetris, AJ
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: February 1993
Date Type: Publication
Journal or Publication Title: Transplant Proc
Volume: 25
Number: 1 Pt 1
Page Range: 669 - 672
Institution: University of Pittsburgh
Refereed: Yes
Uncontrolled Keywords: Actuarial Analysis, Adult, Azathioprine, Drug Therapy, Combination, Follow-Up Studies, Graft Rejection, Graft Survival, Humans, Kidney Function Tests, Kidney Transplantation, Prednisone, Survival Analysis, Tacrolimus
ISSN: 0041-1345
Funders: NIDDK NIH HHS (R01 DK029961-19)
Other ID: uls-drl:31735062112473, Starzl CV No. 1456
Date Deposited: 08 Apr 2010 17:24
Last Modified: 13 Oct 2017 22:55
URI: http://d-scholarship.pitt.edu/id/eprint/4842

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