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Systemic chimerism in human female recipients of male livers

Starzl, TE and Ramos, H and Zeevi, A and Ricordi, C and Ildstad, S and Murase, N and Demetris, AJ and Trucco, M and Rudert, WA and Kocova, M (1992) Systemic chimerism in human female recipients of male livers. The Lancet, 340 (8824). 876 - 877. ISSN 0140-6736

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We have previously reported data from clinical and laboratory animal observations which suggest that organ tolerance after transplantation depends on a state of balanced lymphodendritic cell chimerism between the host and donor graft. We have sought further evidence to support this hypothesis by investigating HLA-mismatched liver allograft recipients. 9 of 9 female recipients of livers from male donors had chimerism in their allografts and extrahepatic tissues, according to in-situ hybridisation and molecular techniques 10 to 19 years post-transplantation. In 8 women with good graft function, evidence of the Y chromosome was found in the blood (6/8), skin (8/8), and lymph nodes (7/8). A ninth patient whose transplant failed after 12 years from recurrent chronic viral hepatitis had chimerism in her lymph nodes, skin, jejunum, and aorta at the time of retransplantation. Although cell migration is thought to take place after all types of transplantation, the large population of migratory cells in, and the extent of their seeding from, hepatic grafts may explain the privileged tolerogenicity of the liver compared with other organs. © 1992.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Starzl, TEtes11@pitt.eduTES11
Ramos, H
Zeevi, A
Ricordi, C
Ildstad, S
Murase, N
Demetris, AJ
Trucco, Mmnt@pitt.eduMNT
Rudert, WA
Kocova, M
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 10 October 1992
Date Type: Publication
Journal or Publication Title: The Lancet
Volume: 340
Number: 8824
Page Range: 876 - 877
DOI or Unique Handle: 10.1016/0140-6736(92)93286-v
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0140-6736
Other ID: uls-drl:31735062112705, Starzl CV No. 1481
Date Deposited: 08 Apr 2010 17:25
Last Modified: 04 Feb 2019 15:58


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