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Sodium lactobionate sucrose solution for canine liver and kidney preservation.

Zhu, Y and Furukawa, H and Nakamura, K and Hamamoto, I and Wu, Y and Xiaoshan, R and Venkataramanan, R and Todo, S and Starzl, TE (1993) Sodium lactobionate sucrose solution for canine liver and kidney preservation. Transplant Proc, 25 (1 Pt 2). 1618 - 1619. ISSN 0041-1345

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With 24-hour preservation of canine liver, SLS solution showed inferior animal survival to UW solution. The lactobionate, raffinose, glutathione, and hydroxyethyl starch in UW solution have been shown to be important for liver preservation. However, our results suggest that sucrose should not be substituted for raffinose for the preservation of livers. In contrast to the liver, SLS solution performed the same or even better than UW solution for kidney preservation. The substitution of sucrose for raffinose, along with the addition of CPZ has either no effect or a slightly positive effect on kidney preservation. In conclusion, SLS solution may be a suitable solution for preserving canine kidneys, but is not suitable for liver preservation. These findings suggest that future development of preservation solutions should be focused on the needs of specific organs and not toward a generic, all encompassing preservation solution.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Zhu, Y
Furukawa, H
Nakamura, K
Hamamoto, I
Wu, Y
Xiaoshan, R
Venkataramanan, Rrv@pitt.eduRV
Todo, S
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: February 1993
Date Type: Publication
Journal or Publication Title: Transplant Proc
Volume: 25
Number: 1 Pt 2
Page Range: 1618 - 1619
Institution: University of Pittsburgh
Refereed: Yes
Uncontrolled Keywords: Animals, Aspartate Aminotransferases, Blood Glucose, Chlorpromazine, Disaccharides, Dogs, Female, Graft Survival, Kidney Transplantation, L-Lactate Dehydrogenase, Liver Function Tests, Liver Transplantation, Organ Preservation, Organ Preservation Solutions, Solutions, Sucrose, Time Factors
ISSN: 0041-1345
Funders: NIDDK NIH HHS (R01 DK029961-19), NIDDK NIH HHS (DK 29961)
Other ID: uls-drl:31735062112994, Starzl CV No. 1508
Date Deposited: 08 Apr 2010 17:25
Last Modified: 13 Oct 2017 21:55


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