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Long-term survival of heart and liver xenografts with splenectomy and FK 506.

Celli, S and Valdivia, LA and Fung, JJ and Demetris, AJ and Marino, IR and Murase, N and Starzl, TE (1993) Long-term survival of heart and liver xenografts with splenectomy and FK 506. Transplant Proc, 25 (1 Pt 1). 647 - 648. ISSN 0041-1345

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Abstract

We have reported that while hamster-to-rat liver xenograft survival is prolonged by FK 506, hamster hearts undergo humoral rejection under this immunosuppressant. Because the spleen has been shown to be one of the main sources of xenoantibodies,, and in vivo experiments have demonstrated that splenectomy (Spx) is able to increase the efficacy of various immunosuppressive agents after xenotransplantation,– we combined Spx with FK 506 to test whether survival of the intractable cardiac xenografts is prolonged, and of liver xenografts improved.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Celli, S
Valdivia, LA
Fung, JJ
Demetris, AJ
Marino, IR
Murase, N
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: February 1993
Date Type: Publication
Journal or Publication Title: Transplant Proc
Volume: 25
Number: 1 Pt 1
Page Range: 647 - 648
Institution: University of Pittsburgh
Refereed: Yes
Uncontrolled Keywords: Animals, Combined Modality Therapy, Cricetinae, Graft Survival, Heart Transplantation, Immunosuppression Therapy, Liver Transplantation, Mesocricetus, Rats, Rats, Inbred Lew, Splenectomy, Tacrolimus, Time Factors, Transplantation, Heterologous
ISSN: 0041-1345
Funders: NIDDK NIH HHS (R01 DK029961-19)
Other ID: uls-drl:31735062113141, Starzl CV No. 1525
Date Deposited: 08 Apr 2010 17:25
Last Modified: 03 Dec 2022 13:56
URI: http://d-scholarship.pitt.edu/id/eprint/4911

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