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Donor cell chimerism permitted by immunosuppressive drugs: a new view of organ transplantation

Starlz, TE and Demetris, AJ and Murase, N and Thomson, AW and Trucco, M and Ricordi, C (1993) Donor cell chimerism permitted by immunosuppressive drugs: a new view of organ transplantation. Immunology Today, 14 (6). 326 - 332. ISSN 0167-5699

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Abstract

On line of thought in organ transplantation feels that immunosuppressive drugs can lead to tolerance induction by allowing a previously unrecognized common mechanism of cell migration and microchimerism to occur perist, and in some cases, become drug independent. It has been recognized that there is a spectrum of susceptibility of different organs to cellular rejection and that the variable ability of these organs to induce donor-specific nonreactivity reflects their comparative content of migratory leukocytes. Here, Thomas Starzl and colleagues discuss how many of the enigmas of transplantation immunology can be explained by this chimerism. © 1993.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Starlz, TE
Demetris, AJ
Murase, N
Thomson, AW
Trucco, M
Ricordi, C
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1993
Date Type: Publication
Journal or Publication Title: Immunology Today
Volume: 14
Number: 6
Page Range: 326 - 332
DOI or Unique Handle: 10.1016/0167-5699(93)90054-o
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0167-5699
Other ID: uls-drl:31735062113190, Starzl CV No. 1528
Date Deposited: 08 Apr 2010 17:25
Last Modified: 13 Oct 2017 22:59
URI: http://d-scholarship.pitt.edu/id/eprint/4914

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