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Lack of association between HLA antigen DR3 and α<inf>1</inf> deficiency in liver transplant recipients

Casavilla, A and Gordon, R and Van Thiel, DH and Starzl, TE (1993) Lack of association between HLA antigen DR3 and α<inf>1</inf> deficiency in liver transplant recipients. Digestive Diseases and Sciences, 38 (8). 1489 - 1491. ISSN 0163-2116

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Abstract

The relationship between α1-antitrypsin deficiency (α-ATD) and the HLA antigen system was studied in 32 liver transplant recipients. Despite previous reports of an association of HLA antigen DR3 with homozygosity for α-AT ZZ, no such association was seen in this population of α-ATD homozygous ZZ patients with advanced hepatic disease. Thus, the reported association of HLA class II antigens and homozygosity for the Z allele for α-AT may be an artifact of either a small study population or geographic inbreeding and a coincidental association of certain HLA antigens with the presence of homozygosity for the Z allele of α-AT. © 1993 Plenum Publishing Corporation.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Casavilla, A
Gordon, R
Van Thiel, DH
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 August 1993
Date Type: Publication
Journal or Publication Title: Digestive Diseases and Sciences
Volume: 38
Number: 8
Page Range: 1489 - 1491
DOI or Unique Handle: 10.1007/bf01308609
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0163-2116
Other ID: uls-drl:31735062113406, Starzl CV No. 1547
Date Deposited: 08 Apr 2010 17:26
Last Modified: 02 Feb 2019 13:57
URI: http://d-scholarship.pitt.edu/id/eprint/4933

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