Casavilla, A and Gordon, R and Van Thiel, DH and Starzl, TE
(1993)
Lack of association between HLA antigen DR3 and α<inf>1</inf> deficiency in liver transplant recipients.
Digestive Diseases and Sciences, 38 (8).
1489 - 1491.
ISSN 0163-2116
Abstract
The relationship between α1-antitrypsin deficiency (α-ATD) and the HLA antigen system was studied in 32 liver transplant recipients. Despite previous reports of an association of HLA antigen DR3 with homozygosity for α-AT ZZ, no such association was seen in this population of α-ATD homozygous ZZ patients with advanced hepatic disease. Thus, the reported association of HLA class II antigens and homozygosity for the Z allele for α-AT may be an artifact of either a small study population or geographic inbreeding and a coincidental association of certain HLA antigens with the presence of homozygosity for the Z allele of α-AT. © 1993 Plenum Publishing Corporation.
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