Valdivia, LA and Fung, JJ and Demetris, AJ and Celli, S and Pan, F and Tsugita, M and Starzl, TE
(1994)
Donor species complement after liver xenotransplantation: The mechanism of protection from hyperacute rejection.
Transplantation, 57 (6).
918 - 922.
ISSN 0041-1337
Abstract
Hamster hearts transplanted into stable rat recipients of hamster livers (OLT rats) were hyperacutely rejected after transfer with unaltered rat antihamster hyperimmune serum (HS). This was followed by immediate liver xenograft rejection in 4 of 5 rats. In contrast, simple heat inactivation of the rat HS resulted in prolonged survival of hamster hearts to 25 days without deterioration effect in the liver xenografts. This effect was species-specific because third-party mouse heart grafts in OLT rats were hyperacutely rejected in minutes if either active or heat inactivated antimouse HS was given. In cytotoxicity experiments, the complement in OLT serum produced weak lysis of hamster lymphocytes, while efficiently doing so with mouse cell targets. Because normal hamster serum caused no lysis at all of hamster target cells, the residual low-grade lysis of OLT serum was possibly being mediated by extrahepatic sources of rat C. In conclusion, the homology of C and target cells represents a mechanism of protection that the liver confers to other organs, and that is most easily seen in xenografts but may be allospecifically operational with allografts as well within the limits of MHC restriction. © 1994 by Williams and Wilkins.
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Item Type: |
Article
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Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID |
---|
Valdivia, LA | | | | Fung, JJ | | | | Demetris, AJ | | | | Celli, S | | | | Pan, F | | | | Tsugita, M | | | | Starzl, TE | tes11@pitt.edu | TES11 | |
|
Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
Date: |
1 January 1994 |
Date Type: |
Publication |
Journal or Publication Title: |
Transplantation |
Volume: |
57 |
Number: |
6 |
Page Range: |
918 - 922 |
DOI or Unique Handle: |
10.1097/00007890-199403270-00025 |
Institution: |
University of Pittsburgh |
Refereed: |
Yes |
ISSN: |
0041-1337 |
Other ID: |
uls-drl:31735062113489, Starzl CV No. 1555 |
Date Deposited: |
08 Apr 2010 17:26 |
Last Modified: |
27 Jan 2019 02:55 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/4941 |
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