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Small intestinal transplantation in humans with or without the colon

Todo, S and Tzakis, A and Reyes, J and Abu-Elmagd, K and Furukawa, H and Nour, B and Casavilla, A and Nakamura, K and Fung, J and Demetris, AJ and Starzl, T (1994) Small intestinal transplantation in humans with or without the colon. Transplantation, 57 (6). 840 - 848. ISSN 0041-1337

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Under FK506-based immunosuppression, 16 cadaveric small bowel transplantations were performed in 15 recipients with (n=5) or without (n=11) the large bowel. Twelve (80%) patients are alive after 1.5 to 19 months, 11 bearing their grafts, of which 4 include colon. The actuarial one-year patient and graft survivals are 87.5% and 65.9%, respectively. Five grafts were lost to acute (n=4) or chronic (n=l) rejection, and 3 of these patients subsequently died after 376, 440, and 776 days total survival. Six recipients developed severe CMV infection that was strongly associated with seronegative status preoperatively and receipt of grafts from CMV positive donors; 3 died, and the other 3 required prolonged hospitalization. Currently, 9 patients are free from TPN 1–18 months postoperatively, 2 require partial TPN, and one has returned to TPN after graft removal. The results show the feasibility of small bowel transplantation but emphasize the difficulty of managing these recipients not only early but long after their operation. © 1994 by Williams and Wilkins.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Todo, S
Tzakis, A
Reyes, J
Abu-Elmagd, K
Furukawa, H
Nour, B
Casavilla, A
Nakamura, K
Fung, J
Demetris, AJ
Starzl, Ttes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1994
Date Type: Publication
Journal or Publication Title: Transplantation
Volume: 57
Number: 6
Page Range: 840 - 848
DOI or Unique Handle: 10.1097/00007890-199403270-00012
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1337
Other ID: uls-drl:31735062113588, Starzl CV No. 1569
Date Deposited: 08 Apr 2010 17:26
Last Modified: 09 Aug 2020 01:55


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