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Small bowel and liver/small bowel transplantation in children.

Reyes, J and Tzakis, AG and Todo, S and Nour, B and Starzl, TE (1993) Small bowel and liver/small bowel transplantation in children. Seminars in pediatric surgery, 2 (4). 289 - 300. ISSN 1055-8586

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A clinical trial of intestinal transplantation was initiated at the University of Pittsburgh in May 1990. Eleven children received either a combined liver/small bowel graft (n = 8) or an isolated small bowel graft (n = 3). Induction as well as maintenance immunosuppression was with FK-506 and steroids. Four patients were male, and seven were female; the age range was 6 months to 10.2 years. There were 3 deaths (all in recipients of the combined liver/small bowel graft), which were attributed to graft-versus-host disease (n = 1), posttransplant lymphoproliferative disease (n = 1), and biliary leak (n = 1). Transplantation of the intestine has evolved into a feasible operation, with an overall patient and graft survival rate of 73%. These survivors are free of total parenteral nutrition, and the majority are home. These encouraging results justify further clinical trials.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Reyes, J
Tzakis, AG
Todo, S
Nour, B
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 November 1993
Date Type: Publication
Journal or Publication Title: Seminars in pediatric surgery
Volume: 2
Number: 4
Page Range: 289 - 300
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 1055-8586
Article Type: Review
Other ID: uls-drl:31735062113786, Starzl CV No. 1588
Date Deposited: 08 Apr 2010 17:27
Last Modified: 19 Jan 2019 13:55


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