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Small‐for‐size liver transplanted into larger recipient: A model of hepatic regeneration

Francavilla, A and Zeng, Q and Polimeno, L and Carr, BI and Sun, D and Porter, KA and van Thiel, DH and Starzl, TE (1994) Small‐for‐size liver transplanted into larger recipient: A model of hepatic regeneration. Hepatology, 19 (1). 210 - 216. ISSN 0270-9139

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Abstract

Orthotopic liver transplantation was performed in 60 recipient rats weighing 200 to 250 gm. Sixty rats of the same strain were used as liver donors, 30 weighing 100 to 140 gm (small for size) and the other 30 weighing 200 to 250 gm (same size). After 1, 2, 3, 4, 7 and 14 days (n = 5 each) DNA synthesis, nuclear thymidine labeling and mitoses were increased in both the small‐for‐size and same‐size groups, but significantly more in the former. These changes were maximal after 48 to 72 hr, similar to but later than the well‐known regeneration response after partial hepatectomy, which peaks at 24 hr in rats. Indirect indexes of regeneration of the transplanted livers also were measured: plasma or serum ornithine decarboxylase; insulin and glucagon serum levels; estradiol and testosterone serum levels (and their nuclear and cytosolic receptors); and transforming growth factor‐ß, c‐Ha‐ras and c‐jun mRNA expressions. With the small‐for‐size transplantation, these followed the same delayed pattern as the direct regeneration parameters. The small livers gradually increased in size over the course of 1 to 2 wk and achieved a volume equal to that of the liver originally present in the recipient. In contrast, no significant liver weight gain occurred in the transplanted livers from same‐size donors despite the evidence of regeneration by direct indexes, but not by most of the surrogate parameters, including ornithine decarboxylase. (Hepatology 1993;19:210–216). Copyright © 1994 American Association for the Study of Liver Diseases


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Francavilla, A
Zeng, Q
Polimeno, L
Carr, BI
Sun, D
Porter, KA
van Thiel, DH
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1994
Date Type: Publication
Journal or Publication Title: Hepatology
Volume: 19
Number: 1
Page Range: 210 - 216
DOI or Unique Handle: 10.1002/hep.1840190131
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0270-9139
Other ID: uls-drl:31735062125780, Starzl CV No. 1599
Date Deposited: 08 Apr 2010 17:27
Last Modified: 04 Nov 2017 05:56
URI: http://d-scholarship.pitt.edu/id/eprint/4985

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