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Evaluation of sequential serum interleukin-6 levels in liver allograft recipients

Kita, Y and Iwaki, Y and Demetris, AJ and Starzl, TE (1994) Evaluation of sequential serum interleukin-6 levels in liver allograft recipients. Transplantation, 57 (7). 1037 - 1041. ISSN 0041-1337

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Abstract

Control serum levels of IL-6 measured by ELISA in 30 healthy blood donors or volunteers were 18±34 pg/ml (mean ± SD). Pretransplant serum levels of IL-6 in 169 adult candidates for liver transplantation were significantly higher than control in those with fulminant hepatitis (203±232 pg/ml), alcoholic cirrhosis (116±257 pg/ml), and hepatocellular carcinoma (82± 105 pg/ml). With these data as background, plasma or serum levels of IL-6 were monitored in 24 adult patients after first OLT and correlated with the clinical courses and the histopathological diagnosis of rejection. Serum or plasma levels of IL-6 decreased after transplantation regardless of pretransplant value. Four patients with infection subsequently developed continuously high IL-6 values. In the 20 of 24 patients who did not have infection, significantly higher levels of IL-6 were consistently found 0-4 days before histopathological diagnosis of rejection (131±78 pg/ml) compared with significantly lower values in patients without rejection episodes (40±21 pg/ml). The elevations of IL-6 were spike shaped, did not correlate well with the histopathological grades of rejection, and were highly responsive to augmented immunosuppression. These 20 cases were classified as: Group 1, no spikes of IL-6 after liver transplantation; group 2, single spike of IL-6 after liver transplantation; and group 3, multiple spikes of IL-6 after liver transplantation. The combined early and late graft loss of each group was 0% (group 1), 25% (group 2), and 67% (group 3). We conclude that daily monitored serum or plasma IL-6 levels can be a good premonitor of liver allograft rejection and also a useful predictor of long-term graft outcome. © 1994 by Williams & Wilkins.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Kita, Y
Iwaki, Y
Demetris, AJ
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1994
Date Type: Publication
Journal or Publication Title: Transplantation
Volume: 57
Number: 7
Page Range: 1037 - 1041
DOI or Unique Handle: 10.1097/00007890-199404150-00009
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1337
Other ID: uls-drl:31735062125848, Starzl CV No. 1605
Date Deposited: 08 Apr 2010 17:27
Last Modified: 27 Jan 2019 02:55
URI: http://d-scholarship.pitt.edu/id/eprint/4991

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