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Reversal of graft-versus-host disease with infusion of autologous bone marrow

Ricordi, C and Tzakis, AG and Zeevi, A and Rybka, WB and Demetris, AJ and Fontes, PAC and Nalesnik, MA and Trucco, M and Ukah, FO and Ball, ED and Mullen, EE and Marino, IR and Fung, JJ and Starzl, TE (1994) Reversal of graft-versus-host disease with infusion of autologous bone marrow. Cell Transplantation, 3 (2). 187 - 192. ISSN 0963-6897

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Graft-versus-host disease (GVHD) remains a major complication of bone marrow transplantation. This report describes reversal of GVHD by infusion of stored recipient bone marrow following combined liver-bone marrow allotransplantation. Graft-versus-host disease developed at the end of the first postoperative week. The skin involvement progressively spread to approximately 80% of the body surface and was not affected by modification of the immunosuppressive treatment. On the 42nd and 43rd postoperative day 1.23 × 108 and 1.6 × 108 autologous bone marrow cells per kg of recipient body weight were infused. The skin rush began to dramatically improve and resolved within 2 wk from the autologous marrow infusion. Autologous bone marrow storage previous to allogeneic bone marrow transplantation for tolerance induction could constitute a safety net in case of occurrence of GVHD. © 1994.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Ricordi, C
Tzakis, AG
Zeevi, A
Rybka, WB
Demetris, AJ
Fontes, PAC
Nalesnik, MAnalesnik@pitt.eduNALESNIK
Trucco, Mmnt@pitt.eduMNT
Ukah, FO
Ball, ED
Mullen, EE
Marino, IR
Fung, JJ
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1994
Date Type: Publication
Journal or Publication Title: Cell Transplantation
Volume: 3
Number: 2
Page Range: 187 - 192
DOI or Unique Handle: 10.1177/096368979400300207
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0963-6897
Other ID: uls-drl:31735062125640, Starzl CV No. 1606
Date Deposited: 08 Apr 2010 17:27
Last Modified: 22 Jun 2021 14:56


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