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Protective effects of the lazaroid U74500A and lidoflazine on liver preservation with UW solution

Jacobsson, J and Sundberg, R and Rilo, HLR and Gasbarrini, A and Starzl, TE and Van Thiel, D (1993) Protective effects of the lazaroid U74500A and lidoflazine on liver preservation with UW solution. Transplant International, 6 (5). 281 - 284. ISSN 0934-0874

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Abstract

The effect of adding a 21-aminosteroid, U74500A, and a Ca 2+ antagonist, lidoflazine, alone and together to UW solution was assessed in a rat liver preservation model. Following preservation, the livers were reperfused using a closed circuit, and the release of hepatocellular enzymes (ASAT, ALAT, and LDH) into the perfusate was determined with increasing time. Both drugs reduced the amount of enzymes lost from the liver. The combination of the two drugs was better than either drug alone. These data suggest that both agents may be of value in organ preservation for clinical liver transplantation. © 1993 Springer-Verlag.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Jacobsson, J
Sundberg, R
Rilo, HLR
Gasbarrini, A
Starzl, TEtes11@pitt.eduTES11
Van Thiel, D
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 September 1993
Date Type: Publication
Journal or Publication Title: Transplant International
Volume: 6
Number: 5
Page Range: 281 - 284
DOI or Unique Handle: 10.1007/bf00336028
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0934-0874
Other ID: uls-drl:31735062125707, Starzl CV No. 1617
Date Deposited: 08 Apr 2010 17:27
Last Modified: 30 Oct 2017 23:56
URI: http://d-scholarship.pitt.edu/id/eprint/5003

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