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Can adenine nucleotides predict primary nonfunction of the human liver homograft?

Hamamoto, I and Takaya, S and Todo, S and Bronsther, O and Fujita, S and Van Gulik, TM and Nakamura, K and Irish, W and Starzl, TE (1994) Can adenine nucleotides predict primary nonfunction of the human liver homograft? Transpl Int, 7 (2). 89 - 95. ISSN 0934-0874

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Abstract

Sixty-eight primary liver grafts were analyzed to see whether adenine nucleotides (AN: ATP, ADP, and AMP) or purine catabolites (PC: adenosine, inosine, hypoxanthine, and xanthine) of tissue or effluent can predict primary graft nonfunction. AN, PC, and nicotinamide adenine dinucleotide, oxidized form (NAD+) of the tissue before (pretransplant) and after graft reperfusion (post-transplant) and of the effluent were analyzed. The graft outcome was classified into two groups (group A: successful, n = 64; group B: primary nonfunctioning, n = 4). No significant differences were observed in pretransplant measurements between groups A and B, whereas ATP, ADP, total AN, total AN + total PC (T) and NAD+, in post-transplant tissues, were significantly higher in group A. Xanthine in the effluent was significantly higher in group B than in group A. ATP, ADP, total AN, T, and NAD+ in post-transplant tissue were significantly associated with primary graft nonfunction by logistic regression analysis.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Hamamoto, I
Takaya, S
Todo, S
Bronsther, O
Fujita, S
Van Gulik, TM
Nakamura, K
Irish, W
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1994
Date Type: Publication
Journal or Publication Title: Transpl Int
Volume: 7
Number: 2
Page Range: 89 - 95
Institution: University of Pittsburgh
Refereed: Yes
Uncontrolled Keywords: Adenine Nucleotides, Adolescent, Adult, Aged, Chromatography, High Pressure Liquid, Female, Graft Rejection, Graft Survival, Humans, Liver Transplantation, Male, Middle Aged, NAD, Purines, Transplantation, Homologous
ISSN: 0934-0874
Funders: NIDDK NIH HHS (R01 DK029961-19), NIDDK NIH HHS (DK 29961)
Other ID: uls-drl:31735062125723, Starzl CV No. 1621
Date Deposited: 08 Apr 2010 17:27
Last Modified: 30 Oct 2017 23:56
URI: http://d-scholarship.pitt.edu/id/eprint/5007

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