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Abdominal multivisceral transplantation

Todo, S and Tzakis, A and Abu-Elmagd, K and Reyes, J and Furukawa, H and Nour, B and Fung, J and Demetris, A and Starzl, TE (1995) Abdominal multivisceral transplantation. Transplantation, 59 (2). 234 - 240. ISSN 0041-1337

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Under FK506-based immunosuppression, 13 abdominal multivisceral transplantations were performed in 6 children and 7 adults. Of the 13 recipients, 7 (53.8%) are alive and well with functioning grafts after 9 to 31 months. Six recipients died: Three from PTLD, one from rejection, one from sepsis, and one from respiratory failure. In addition to rejection, postoperative complications occurring in more than isolated cases included PTLD (n=6), abdominal abscess formation (n=5), pancreatitis (n=3), and ampullary dysfunction (n=2). In addition, infection by enteric microorganisms was common during the early postoperative period. Currently, all 7 survivors are on an oral diet and have normal liver function. Two recipients (one insulin-dependent) require antidiabetes treatment, in one case following distal pancreatectomy and in the other after two episodes of pancreatic rejection. Thus, abdominal multivisceral transplantation is a difficult but feasible operation that demands complex and prolonged posttransplantation management. It is not yet ready for application and awaits a better strategy of immune modulation. © 1995 by Williams & Wilkins.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Todo, S
Tzakis, A
Abu-Elmagd, K
Reyes, J
Furukawa, H
Nour, B
Fung, J
Demetris, A
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1995
Date Type: Publication
Journal or Publication Title: Transplantation
Volume: 59
Number: 2
Page Range: 234 - 240
DOI or Unique Handle: 10.1097/00007890-199501270-00015
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1337
Other ID: uls-drl:31735062125954, Starzl CV No. 1625
Date Deposited: 08 Apr 2010 17:27
Last Modified: 06 Jun 2020 13:55


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