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Parvovirus B19 infection in pediatric transplant patients

Nour, B and Green, M and Michaels, M and Reyes, J and Tzakis, A and Gartner, JC and McLoughlin, L and Starzl, TE (1993) Parvovirus B19 infection in pediatric transplant patients. Transplantation, 56 (4). 835 - 838. ISSN 0041-1337

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Evidence of recent parvovirus virus infection (as determined by the presence of a positive IgM antibody titer) without other identified causes of anemia was found in 5 of 26 pediatric solid-organ transplant recipients evaluated for moderate-to-severe anemia between June 1990 and July 1991. Anemia tended to be chronic (median duration of anemia at the time of diagnosis was 12 weeks) and was associated with normal red blood cell indices in the absence of reticulocytes. The median age of the children at the time of presentation with anemia due to parvovirus was 1.8 years at a median time of 8 months after transplantation. Four of the 5 children were treated with i.v. immunoglobulin because of persistance of anemia requiring blood transfusions. A response characterized by an increase in reticulocyte count and normalization of hemoglobin was seen in each of these patients 2-4 weeks after treatment. The remaining patient experienced a spontaneous recovery from her anemia. Parvovirus infection should be included in the differential diagnosis of solid-organ transplant recipients presenting with severe anemia associated with low or absent reticulocytes.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Nour, B
Green, Mgreenm@pitt.eduGREENM
Michaels, M
Reyes, J
Tzakis, A
Gartner, JC
McLoughlin, L
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1993
Date Type: Publication
Journal or Publication Title: Transplantation
Volume: 56
Number: 4
Page Range: 835 - 838
DOI or Unique Handle: 10.1097/00007890-199310000-00011
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1337
Other ID: uls-drl:31735062125913, Starzl CV No. 1628
Date Deposited: 08 Apr 2010 17:27
Last Modified: 02 Aug 2020 10:58


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