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Decreased incidence of viral infections in liver transplant recipients - Possible effects of FK506?

Singh, N and Mieles, L and Yu, VL and Starzl, TE (1994) Decreased incidence of viral infections in liver transplant recipients - Possible effects of FK506? Digestive Diseases and Sciences, 39 (1). 15 - 18. ISSN 0163-2116

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Abstract

Cytomegalovirus (CMV) is a major infectious complication of organ transplantation and its incidence is influenced by the type and intensity of immunosuppressive therapy employed. Using a new immunosuppressive agent FK506, CMV infection was observed in 30% and CMV disease in 15% of the 26 liver transplant recipients. Delayed onset of CMV disease was noted; the mean time to the occurrence of CMV disease being 137 days posttransplantation. No graft loss or mortality could be attributed to CMV infection. Mucocutaneous herpes simplex virus (HSV) infections were encountered in 19% of the patients, while no disease could be attributed to varicella zoster virus or Epstein-Barr virus (EBV). The contribution of FK506 to a decrease in viral morbidity and associated mortality bears further investigation. © 1994 Plenum Publishing Corporation.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Singh, N
Mieles, L
Yu, VL
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1994
Date Type: Publication
Journal or Publication Title: Digestive Diseases and Sciences
Volume: 39
Number: 1
Page Range: 15 - 18
DOI or Unique Handle: 10.1007/bf02090054
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0163-2116
Other ID: uls-drl:31735062125624, Starzl CV No. 1651
Date Deposited: 08 Apr 2010 17:28
Last Modified: 13 Oct 2017 21:56
URI: http://d-scholarship.pitt.edu/id/eprint/5037

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