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Amelioration of intestinal dysmotility and stasis by octreotide early after small-bowel autotransplantation in dogs

Nakada, K and Ikoma, A and Suzuki, T and Reynolds, JC and Campbell, WL and Todo, S and Starzl, TE (1995) Amelioration of intestinal dysmotility and stasis by octreotide early after small-bowel autotransplantation in dogs. American Journal of Surgery, 169 (3). 294 - 299. ISSN 0002-9610

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Abstract

Intestinal dysmotility and stasis after intestinal transplantation are considered to promote bacterial overgrowth and translocation. Two prokinetic agents, KW5139 (13-leu-motilin) and the somatostatin analogue octreotide acetate, were studied to determine whether they can ameliorate intestinal dysmotility during the early postoperative period. Motility was recorded by multiple extraluminal strain-gauge transducers in 6 dogs on postoperative days 1, 3, 7, and 14. A barium meal study was performed with a separate group of 8 dogs on postoperative days 3 and 7. The agent KW5139 induced brief, weak contractions in the graft and had little effect on the dilated bowel; however, octreotide induced motor activity that propelled accumulated intestinal contents into the colon and reduced dilation of the transplanted bowel. Octreotide, but not KW5139, ameliorates intestinal dysmotility associated with bowel autotransplantation during the early postoperative period. Short-term administration of octreotide may be useful for the treatment of dysmotility following intestinal transplantation. © 1995, All rights reserved.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Nakada, K
Ikoma, A
Suzuki, T
Reynolds, JC
Campbell, WL
Todo, S
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1995
Date Type: Publication
Journal or Publication Title: American Journal of Surgery
Volume: 169
Number: 3
Page Range: 294 - 299
DOI or Unique Handle: 10.1016/s0002-9610(99)80161-5
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0002-9610
Other ID: uls-drl:31735062125129, Starzl CV No. 1657
Date Deposited: 08 Apr 2010 17:28
Last Modified: 14 Oct 2017 03:55
URI: http://d-scholarship.pitt.edu/id/eprint/5043

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