Saidman, SL and Duquesnoy, RJ and Demetris, AJ and McCauley, J and Ramos, H and Mazariegos, G and Shapiro, R and Starzl, TE and Fung, JJ
(1994)
Combined liver-kidney transplantation and the effect of preformed lymphocytotoxic antibodies.
Transplant Immunology, 2 (1).
61 - 67.
ISSN 0966-3274
Abstract
Thirty-eight sequentially placed liver and kidney allografts were evaluated with respect to patient and graft survival, and the influence of preformed lymphocytotoxic antibodies was analysed. The results suggest that the survival rate of combined liver and kidney transplantation is similar to the survival rate of liver transplantation alone. Sequentially placed kidney allografts may be protected from hyperacute rejection in the presence of donor specific lymphocytotoxic antibodies, but not in all instances. Both patient and kidney allograft survival was lower in positive crossmatch patients (33% and 17% respectively) than in negative crossmatch patients (78% and 75%). High levels of panel reactive antibodies (>10%) also appeared to have a deleterious effect on survival, although the majority of the patients who failed also had a positive crossmatch. Although preformed lymphocytotoxic antibodies are not an absolute contraindication to combined liver-kidney transplantation, they do appear to have a deleterious effect on long-term graft survival. However, more correlation with clinical parameters is needed. © 1994.
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| Item Type: |
Article
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| Status: |
Published |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Saidman, SL | | | | | Duquesnoy, RJ | | | | | Demetris, AJ | | | | | McCauley, J | | | | | Ramos, H | | | | | Mazariegos, G | | | | | Shapiro, R | | | | | Starzl, TE | tes11@pitt.edu | TES11 | | | Fung, JJ | | | |
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| Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
| Date: |
1 January 1994 |
| Date Type: |
Publication |
| Journal or Publication Title: |
Transplant Immunology |
| Volume: |
2 |
| Number: |
1 |
| Page Range: |
61 - 67 |
| DOI or Unique Handle: |
10.1016/0966-3274(94)90080-9 |
| Institution: |
University of Pittsburgh |
| Refereed: |
Yes |
| ISSN: |
0966-3274 |
| Other ID: |
uls-drl:31735062125152, Starzl CV No. 1664 |
| Date Deposited: |
08 Apr 2010 17:28 |
| Last Modified: |
27 Jan 2019 02:55 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/5050 |
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