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Long-term results after liver transplantation for primary hepatic epithelioid hemangioendothelioma

Madariaga, JR and Marino, IR and Karavias, DD and Nalesnik, MA and Doyle, HR and Iwatsuki, S and Fung, JJ and Starzl, TE (1995) Long-term results after liver transplantation for primary hepatic epithelioid hemangioendothelioma. Annals of Surgical Oncology, 2 (6). 483 - 487. ISSN 1068-9265

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Abstract

Background: Hepatic epithelioid hemangioendothelioma (PHEHE) is a multifocal, low-grade malignant neoplasia characterized by its epithelial-like appearance and vascular endothelial histogenesis. The outcome of 16 patients treated with orthotopic liver transplantation (OLT) is the subject of this report. Methods: A retrospective study of 16 patients with HEHE (7 men, 9 women) with ages ranging from 24 to 58 years (mean 37 ± 10.6 years). Follow-up intervals ranged from 1 to 15 years (median of 4.5 years). Results: Actual patient survival at 1, 3, and 5 years was 100, 87.5, and 71.3%, respectively. Disease-free survival at 1, 3, and 5 years was 81.3, 68.8, and 60.2%, respectively. The 90-day operative mortality was 0. Involvement of the hilar lymph nodes or vascular invasion did not affect survival. The 5-year survival of HEHE compares favorably with that of hepatocellular carcinoma at the same stage (stage 4A): 71.3 versus 9.8% (p=0.001) Conclusions: The long-term survival obtained in this series justifies OLT for these tumors even in the presence of limited extrahepatic disease. © 1995 The Society of Surgical Oncology, Inc.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Madariaga, JR
Marino, IR
Karavias, DD
Nalesnik, MAnalesnik@pitt.eduNALESNIK
Doyle, HR
Iwatsuki, S
Fung, JJ
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 November 1995
Date Type: Publication
Journal or Publication Title: Annals of Surgical Oncology
Volume: 2
Number: 6
Page Range: 483 - 487
DOI or Unique Handle: 10.1007/bf02307080
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 1068-9265
Other ID: uls-drl:31735062125178, Starzl CV No. 1667
Date Deposited: 08 Apr 2010 17:28
Last Modified: 29 Jan 2019 15:55
URI: http://d-scholarship.pitt.edu/id/eprint/5053

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