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Rejection of human intestinal allografts: Alone or in combination with the liver

Abu-Elmagd, K and Todo, S and Tzakis, A and Furukawa, H and Nour, B and Reyes, J and Nakamura, K and Scotti-Foglieni, C and El-Hammadi, H and Kadry, Z and Fung, J and Demetris, J and Starzl, TE (1994) Rejection of human intestinal allografts: Alone or in combination with the liver. Transplantation Proceedings, 26 (3). 1430 - 1431. ISSN 0041-1345

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Abstract

The current results of the present series demonstrate that intestinal allografts are more vulnerable to rejection and continue to be at a significantly higher risk long after transplantation compared with isolated liver allograft recipients. Unexpectedly, a combined liver allograft does not protect small bowel from rejection. The necessarily continuous heavy immunosuppression for these unique recipients is potentially self-defeating. This is clearly demonstrated by their high susceptibility to early and late infectious complications after transplantation as reported in this issue. With the minimal graft-versus-host disease threat in this clinical trial, our revised protocol for future intestinal transplantation is to maximize the passenger leukocyte traffic with supplementary bone marrow from the same intestinal donor in an attempt to augment the development of systemic chimerism and the gradual induction of donor-specific nonreactivity.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Abu-Elmagd, K
Todo, S
Tzakis, A
Furukawa, H
Nour, B
Reyes, J
Nakamura, K
Scotti-Foglieni, C
El-Hammadi, H
Kadry, Z
Fung, J
Demetris, J
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 15 July 1994
Date Type: Publication
Journal or Publication Title: Transplantation Proceedings
Volume: 26
Number: 3
Page Range: 1430 - 1431
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1345
Other ID: uls-drl:31735062124882, Starzl CV No. 1688
Date Deposited: 08 Apr 2010 17:28
Last Modified: 11 Dec 2017 02:55
URI: http://d-scholarship.pitt.edu/id/eprint/5074

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