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Xenobiotics, chimerism and the induction of tolerance following organ transplantation

Delaney, CP and Thomson, AW and Demetris, AJ and Starzl, TE (1994) Xenobiotics, chimerism and the induction of tolerance following organ transplantation. Therapeutic Immunology, 1 (3). 153 - 164. ISSN 0967-0149

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The successful results seen after organ transplantation are largely attributable to the potency and specificity of modern immunosuppressive agents. Although drug-free unresponsiveness to graft alloantigens has not been routinely achieved in clinical practice, recent appreciation of the importance of cell chimerism, which develops after the migration from donor to host of leukocytes contained in solid organ grafts, has introduced a concept which may explain the mechanism of graft tolerance. Recent evidence has indicated that immunosuppressive drugs may have a common potential to induce graft tolerance, even though they act through diverse mechanisms, and that this potential may be mediated by a permissive effect on the migration and survival of donor-derived leukocytes. This review briefly examines the mechanisms by which immunosuppressive drugs function and analyses the different methods which these agents might use to induce chimerism associated with graft tolerance. Furthermore, we describe ongoing clinical studies in which the chimerism produced after solid organ transplantation is augmented with donor bone marrow in an attempt to facilitate the induction of tolerance.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Delaney, CP
Thomson, AW
Demetris, AJ
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 9 September 1994
Date Type: Publication
Journal or Publication Title: Therapeutic Immunology
Volume: 1
Number: 3
Page Range: 153 - 164
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0967-0149
Other ID: uls-drl:31735062126556, Starzl CV No. 1720
Date Deposited: 08 Apr 2010 17:29
Last Modified: 04 Feb 2019 15:57


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