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Heteroagglutinins and their significance in baboon hepatic xenotransplantation

Triulzi, DJ and Jochum, EA and Marino, IR and Starzl, TE (1995) Heteroagglutinins and their significance in baboon hepatic xenotransplantation. Transplantation, 60 (2). 127 - 131. ISSN 0041-1337

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Abstract

The role of preformed xenoreactive antibodies in xenograft recipients is unknown. Humans and baboons possess red cell agglutinating activity associated with isohemagglutinins and heteroagglutinins (HA). We examined the role of HA in two patients who received ABO-identical baboon livers. Human antibaboon HA were assessed by correlating serial titers with studies for rejection. Serial direct antiglobulin testing (DAT) was used to detect baboon antihuman HA, potentially produced by transplanted passenger lymphocytes. Patient 1 survived 70 days. The human antibaboon HA titers remained essentially unchanged from preoperative values. Although hyperacute rejection did not occur, and there was only mild cellular rejection, liver function was suboptimal. Postreperfusion immunoglobulin and complement deposition and histologic changes suggested complement-mediated injury. DAT testing was negative except for passively acquired anti-A from transfusion. At autopsy there was marked bile stasis, but no rejection. Patient 2 survived 26 days with essentially unchanged HA titers until preterminal. Although there was no hyperacute rejection and only mild humoral rejection (without cellular rejection), suboptimal liver function and bile stasis were again noted. Postreperfusion immunoglobulin and complement deposition again suggested com-plement-mediated injury. DAT testing was negative. At autopsy there was no rejection. Human antibaboon HA do not appear to be associated with hyperacute or cellular rejection, but their role in the complement-mediated injury, suspected in both cases, cannot be definitively excluded. Baboon antihuman HA were not detected in either patient. © 1995 by Williams and Wilkins.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Triulzi, DJtriulzi@pitt.eduTRIULZI
Jochum, EA
Marino, IR
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 27 July 1995
Date Type: Publication
Journal or Publication Title: Transplantation
Volume: 60
Number: 2
Page Range: 127 - 131
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1337
Other ID: uls-drl:31735062126598, Starzl CV No. 1778
Date Deposited: 08 Apr 2010 17:30
Last Modified: 01 Nov 2017 14:07
URI: http://d-scholarship.pitt.edu/id/eprint/5164

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