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Immune status of recipients following bone marrow - Augmented solid organ transplantation

Zeevi, A and Pavlick, M and Lombardozzi, S and Banas, R and Pappo, O and Rao, AS and Fontes, P and Demetris, J and Shapiro, R and Dodson, F and Trucco, M and Carroll, P and Pham, S and Fung, JJ and Starzl, TE (1995) Immune status of recipients following bone marrow - Augmented solid organ transplantation. Transplantation, 59 (4). 616 - 620. ISSN 0041-1337

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Abstract

It has been postulated that the resident “passenger” leukocytes of hematolymphoid origin that migrate from whole organ grafts and subsequently establish systemic chimerism are essential for graft acceptance and the induction of donor-specific nonreactivity. This phenomenon was augmented by infusing 3 × 10 < sup > 8 < /sup > unmodified donor bone-marrow cells into 40 patients at the time of organ transplantation. Fifteen of the first 18 analyzable patients had sequential immunological evaluation over postoperative intervals of 5 to 17 months, (which included 7 kidney (two with islets), 7 liver (one with islets), and one heart recipient). The evolution of changes was compared with that in 16 kidney and liver nonmarrow controls followed for 4 to5 months. The generic immune reactivity of peripheral blood mononuclear cells (PBMC) was determined by their proliferative responses to mitogens (PHA, ConA). Alloreactivity was measured by the recipient mixed lymphocyte reaction (MLR) to donor and HLA-mis-matched third-party panel cells. Based on all 3 tests,the recipients were classified as donor-specific hyporeactive, intermediate, and responsive; patients who were globally suppressed made up a fourth category. Eight (53%) of the 15 marrow-treated recipients exhibited progressive modulation of donor-specific reactivity (3 hyporeactive and 5 intermediate) while 7 remained antidonor-responsive. In the nonmarrow controls, 2 (12.5%) of the 16 patients showed donor-specific hyporeactivity, 10 (62.5%) were reactive, and 4 (25%) studied during a CMV infection had global suppression of responsiveness to all stimuli. © 1995 by Williams and Wilkins.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Zeevi, A
Pavlick, M
Lombardozzi, S
Banas, R
Pappo, O
Rao, AS
Fontes, P
Demetris, J
Shapiro, R
Dodson, F
Trucco, M
Carroll, P
Pham, S
Fung, JJ
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 27 February 1995
Date Type: Publication
Journal or Publication Title: Transplantation
Volume: 59
Number: 4
Page Range: 616 - 620
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1337
Other ID: uls-drl:31735062126838, Starzl CV No. 1790
Date Deposited: 08 Apr 2010 17:30
Last Modified: 13 Oct 2017 22:59
URI: http://d-scholarship.pitt.edu/id/eprint/5176

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