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Myocardial ischemia after orthotopic liver transplantation

Rubin, DA and Schulman, DS and Edwards, TD and Starzl, TE and Curtiss, EI (1994) Myocardial ischemia after orthotopic liver transplantation. The American Journal of Cardiology, 74 (1). 53 - 56. ISSN 0002-9149

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Abstract

A hypercoagulable state exists after orthotopic liver transplantation. This hematologic abnormality may predispose patients to coronary thrombosis and unstable angina. The incidence of post-operative myocardial ischemia in such patients is unknown. Suitable electrocardiograms and clinical events of consecutive patients undergoing orthotopic liver transplantation (n = 45) and major intraabdominal surgery (n = 28) during a 3-month period at a major university teaching hospital and transplant center were examined retrospectively. Clinical myocardial ischemia or ischemic electrocardiographic changes, or both, occurred in 6 transplant patients compared with no patient in the nontransplant or comparison group. In 4 of the 6 patients with dramatic electrocardiographic changes and ischemic events, coronary arteriography failed to demonstrate significant obstructive disease. It is concluded that severe myocardial ischemia may occur in patients after orthotopic liver transplantation in the absence of significant coronary disease. A hypercoagulable state may predispose to coronary thrombosis in this setting, providing insight (and a future model for study) into the development of unstable angina. © 1994.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Rubin, DA
Schulman, DS
Edwards, TD
Starzl, TEtes11@pitt.eduTES11
Curtiss, EI
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 July 1994
Date Type: Publication
Journal or Publication Title: The American Journal of Cardiology
Volume: 74
Number: 1
Page Range: 53 - 56
DOI or Unique Handle: 10.1016/0002-9149(94)90491-x
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0002-9149
Other ID: uls-drl:31735062126713, Starzl CV No. 1802
Date Deposited: 08 Apr 2010 17:30
Last Modified: 16 Oct 2017 05:55
URI: http://d-scholarship.pitt.edu/id/eprint/5188

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