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Effect of donor age and sex on the outcome of liver transplantation

Marino, IR and Doyle, HR and Aldrighetti, L and Doria, C and McMichael, J and Gayowski, T and Fung, JJ and Tzakis, AG and Starzl, TE (1995) Effect of donor age and sex on the outcome of liver transplantation. Hepatology, 22 (6). 1754 - 1762. ISSN 0270-9139

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We correlated donor and recipient factors with graft outcome in 436 adult patients who underwent 462 liver transplants. Donor variables analyzed were age, gender, ABO blood group, cause of death, length of stay in the intensive care unit, use of pressors or pitressin, need for cardiopulmonary resuscitation, terminal serum transaminases, and ischemia time. Recipient variables analyzed were age, gender, primary diagnosis, history of previous liver transplant, ABO blood group, cytotoxic antibody crossmatch, United Network for Organ Sharing (UNOS) status, and waiting time (except for the cross-match results, they were all known at the time of the operation). The endpoint of the analysis was graft failure, defined as patient death or retransplantation. Using multivariate analysis, graft failure was significantly associated with donor age, donor gender, previous liver transplantation, and UNOS 4 status of the recipient. The effect of donor age became evident only when they were older than 45 years. Livers from female donors yielded significantly poorer results, with 2-year graft survival of female to male 55% (95% CI, 45% to 67%); female to female, 64% (95% CI, 54% to 77%); male to male, 72% (95% CI, 66% to 78%); and male to female, 78% (95% CI, 70% to 88%). The only donors identified as questionable for liver procurement were old (-60 years) women in whom the adverse age and gender factors were at least additive. However, rather than discard even these livers, in the face of an organ shortage crisis, their individualized use is suggested with case reporting in a special category. © 1995.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Marino, IR
Doyle, HR
Aldrighetti, L
Doria, C
McMichael, J
Gayowski, T
Fung, JJ
Tzakis, AG
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1995
Date Type: Publication
Journal or Publication Title: Hepatology
Volume: 22
Number: 6
Page Range: 1754 - 1762
DOI or Unique Handle: 10.1016/0270-9139(95)90202-3
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0270-9139
Other ID: uls-drl:31735062126697, Starzl CV No. 1804
Date Deposited: 08 Apr 2010 17:30
Last Modified: 02 Feb 2019 13:58


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