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Perioperative donor bone marrow infusion augments chimerism in heart and lung transplant recipients

Pham, SM and Keenan, RJ and Rao, AS and Fontes, PA and Kormos, RL and Abu-Elmagd, K and Zeevi, A and Kawai, A and Hattler, BG and Hardesty, RL and Demetris, AJ and Trucco, MM and Rosner, GL and Fung, JJ and Starzl, TE and Griffith, BP (1995) Perioperative donor bone marrow infusion augments chimerism in heart and lung transplant recipients. The Annals of Thoracic Surgery, 60 (4). 1015 - 1020. ISSN 0003-4975

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Background.: We and others have demonstrated that a low level of donor cell chimerism was present for years after transplantation in tissues and peripheral blood of heart and lung recipients; it was associated, in the latter, with a lower incidence of chronic rejection. To augment this phenomenon, we initiated a trial combining simultaneous infusion of donor bone marrow with heart or lung allotransplantation. Methods.: Between September 1993 and January 1995, 15 nonconditioned patients received either heart (n = 10) or lung (n = 5) allografts concurrently with an infusion of unmodified donor bone marrow (3.0 × 108 cells/kg), and were maintained on an immunosuppressive regimen consisting of tacrolimus and steroids. Results.: There was no complication associated with the infusion of donor bone marrow. Chimerism was detectable in 73% of bone marrow-augmented patients up to the last sample tested. Of the 5 control recipients who did not receive bone marrow infusion, only 1 had detectable chimerism by flow on postoperative day 15, which dwindled to an undetectable level by postoperative day 36. None of the patients had evidence of donor-specific immune modulation by mixed lymphocyte reaction. Conclusions.: The combined infusion of donor bone marrow and heart or lung transplantation, without preconditioning of the recipient, is safe and is associated with an augmentation of donor cell chimerism. © 1995 The Society of Thoracic Surgeons.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Pham, SM
Keenan, RJ
Rao, AS
Fontes, PA
Kormos, RLkormos@pitt.eduKORMOS
Abu-Elmagd, K
Zeevi, A
Kawai, A
Hattler, BG
Hardesty, RL
Demetris, AJ
Trucco, MMmnt@pitt.eduMNT
Rosner, GL
Fung, JJ
Starzl, TEtes11@pitt.eduTES11
Griffith, BP
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1995
Date Type: Publication
Journal or Publication Title: The Annals of Thoracic Surgery
Volume: 60
Number: 4
Page Range: 1015 - 1020
DOI or Unique Handle: 10.1016/0003-4975(95)00579-a
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0003-4975
Other ID: uls-drl:31735062133099, Starzl CV No. 1845
Date Deposited: 08 Apr 2010 17:31
Last Modified: 22 Jun 2021 14:56


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