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The superiority of tacrolimus in renal transplant recipients -- the Pittsburgh experience.

Shapiro, R and Jordan, ML and Scantlebury, VP and Vivas, C and Gritsch, HA and Corry, RJ and Egidi, F and McCauley, J and Ellis, D and Gilboa, N (1995) The superiority of tacrolimus in renal transplant recipients -- the Pittsburgh experience. Clinical transplants. 199 - 205. ISSN 0890-9016

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Abstract

Tacrolimus is a superior immunosuppressive agent in patients undergoing renal transplantation. In adults, the 1- and 3-year actuarial patient survivals were 95% and 92%, and the 1- and 3-year actuarial graft survivals were 89% and 80%. For first cadaver kidneys, the 1- and 3-year actuarial graft survivals were 91% and 82%, with a projected half-life of 11.9 years. Sixty-nine percent of successfully transplanted patients were weaned off steroids. In pediatric patients, the 1- and 4-year actuarial patient survivals were 100% and 96%, and the 1- and 4-year actuarial graft survivals were 99% and 85%. Seventy-three percent of successfully transplanted children were weaned off steroids. Tacrolimus was also useful as a rescue agent, with an initial success rate of 74%. Tacrolimus has been used successfully in kidney/ pancreas transplantation, with 100% patient, 95% kidney, and 79% pancreas graft survival. Tacrolimus should be considered the immunosuppressive agent of choice in renal transplantation.


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Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Shapiro, R
Jordan, ML
Scantlebury, VP
Vivas, C
Gritsch, HA
Corry, RJ
Egidi, F
McCauley, J
Ellis, D
Gilboa, N
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1995
Date Type: Publication
Journal or Publication Title: Clinical transplants
Page Range: 199 - 205
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0890-9016
Article Type: Review
Other ID: uls-drl:31735062133164, Starzl CV No. 1852
PubMed ID: 8794266
Date Deposited: 08 Apr 2010 17:31
Last Modified: 08 Feb 2019 15:55
URI: http://d-scholarship.pitt.edu/id/eprint/5238

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