Randhawa, PS and Tsamandas, AC and Magnone, M and Jordan, M and Shapiro, R and Starzl, TE and Demetris, AJ
(1996)
Microvascular changes in renal allografts associated with FK506 (Tacrolimus) therapy.
American Journal of Surgical Pathology, 20 (3).
306 - 312.
ISSN 0147-5185
Abstract
FK506 (Tacrolimus) recently has been shown to be an effective immunosuppressant after renal transplantation. It is associated with less hypertension, hypercholesterolemia and steroid use compared with cyclosporine. We report 10 patients on FK506 who showed fibrin thrombi within the glomerular capillaries and/or arterioles at renal allograft biopsy. These biopsies were generally performed to assess increasing serum creatinine levels; laboratory evidence of hemolytic uremic syndrome was present in one instance. Plasma or whole blood FK506 levels were elevated in eight of 10 cases. Reduction of immunosuppression led to clinical improvement or biopsy- proven resolution of thrombi in all cases. These observations suggest that FK506 may occasionally produce microvascular changes in the renal allograft. The estimated incidence of this occurrence (1%) is comparable with that reported with cyclosporine (3%).
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Item Type: |
Article
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Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID |
---|
Randhawa, PS | | | | Tsamandas, AC | | | | Magnone, M | | | | Jordan, M | | | | Shapiro, R | | | | Starzl, TE | tes11@pitt.edu | TES11 | | Demetris, AJ | | | |
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Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
Date: |
1 March 1996 |
Date Type: |
Publication |
Journal or Publication Title: |
American Journal of Surgical Pathology |
Volume: |
20 |
Number: |
3 |
Page Range: |
306 - 312 |
DOI or Unique Handle: |
10.1097/00000478-199603000-00007 |
Institution: |
University of Pittsburgh |
Refereed: |
Yes |
ISSN: |
0147-5185 |
Other ID: |
uls-drl:31735062133347, Starzl CV No. 1870 |
Date Deposited: |
08 Apr 2010 17:32 |
Last Modified: |
05 Feb 2019 01:55 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/5256 |
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