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Microvascular changes in renal allografts associated with FK506 (Tacrolimus) therapy

Randhawa, PS and Tsamandas, AC and Magnone, M and Jordan, M and Shapiro, R and Starzl, TE and Demetris, AJ (1996) Microvascular changes in renal allografts associated with FK506 (Tacrolimus) therapy. American Journal of Surgical Pathology, 20 (3). 306 - 312. ISSN 0147-5185

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FK506 (Tacrolimus) recently has been shown to be an effective immunosuppressant after renal transplantation. It is associated with less hypertension, hypercholesterolemia and steroid use compared with cyclosporine. We report 10 patients on FK506 who showed fibrin thrombi within the glomerular capillaries and/or arterioles at renal allograft biopsy. These biopsies were generally performed to assess increasing serum creatinine levels; laboratory evidence of hemolytic uremic syndrome was present in one instance. Plasma or whole blood FK506 levels were elevated in eight of 10 cases. Reduction of immunosuppression led to clinical improvement or biopsy- proven resolution of thrombi in all cases. These observations suggest that FK506 may occasionally produce microvascular changes in the renal allograft. The estimated incidence of this occurrence (1%) is comparable with that reported with cyclosporine (3%).


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Randhawa, PS
Tsamandas, AC
Magnone, M
Jordan, M
Shapiro, R
Starzl, TEtes11@pitt.eduTES11
Demetris, AJ
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 March 1996
Date Type: Publication
Journal or Publication Title: American Journal of Surgical Pathology
Volume: 20
Number: 3
Page Range: 306 - 312
DOI or Unique Handle: 10.1097/00000478-199603000-00007
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0147-5185
Other ID: uls-drl:31735062133347, Starzl CV No. 1870
Date Deposited: 08 Apr 2010 17:32
Last Modified: 05 Feb 2019 01:55


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