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Graft-versus-host disease after liver and small bowel transplantation in a child.

Reyes, J and Todo, S and Green, M and Yunis, E and Schoner, D and Kocoshis, S and Furukawa, H and Abu-Elmagd, K and Tzakis, A and Bueno, J and Starzl, TE (1997) Graft-versus-host disease after liver and small bowel transplantation in a child. Clin Transplant, 11 (5 Pt 1). 345 - 348. ISSN 0902-0063

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An 8-month-old child with an immunodeficiency disorder characterized by abnormal lymphocyte function and by low IgG and IgA levels had combined liver and small bowel transplantation under tacrolimus and steroid immunosuppression for the treatment of short gut syndrome and hepatic cirrhosis. The patient developed an early postoperative episode of Pneumocystis carinii pneumonia, and a subsequent surgical complication, prompting discontinuance of tacrolimus. A skin rash eventually shown to be graft-versus-host disease (GVHD) developed in the flank on the 12th post-transplant day and gradually became generalized. Peritonitis, sepsis, multisystem organ failure including the liver allograft led to death on the 23rd post-operative day. The mechanisms leading to post-transplant GVHD under the specific circumstances in this case are discussed.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Reyes, J
Todo, S
Green, M
Yunis, E
Schoner, D
Kocoshis, S
Furukawa, H
Abu-Elmagd, K
Tzakis, A
Bueno, J
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: October 1997
Date Type: Publication
Journal or Publication Title: Clin Transplant
Volume: 11
Number: 5 Pt 1
Page Range: 345 - 348
Institution: University of Pittsburgh
Refereed: Yes
Uncontrolled Keywords: Exanthema, Fatal Outcome, Female, Glucocorticoids, Graft vs Host Disease, Humans, IgA Deficiency, IgG Deficiency, Immunologic Deficiency Syndromes, Immunosuppressive Agents, Infant, Intestine, Small, Ischemia, Liver, Liver Cirrhosis, Liver Transplantation, Lymphocytes, Methylprednisolone, Multiple Organ Failure, Peritonitis, Pneumonia, Pneumocystis, Sepsis, Short Bowel Syndrome, Tacrolimus
ISSN: 0902-0063
Funders: NIDDK NIH HHS (R01 DK029961-19), NIDDK NIH HHS (DK 29961)
Other ID: uls-drl:31735062133909, Starzl CV No. 1925
Date Deposited: 08 Apr 2010 17:32
Last Modified: 13 Oct 2017 21:56


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