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Indocyanine green elimination test in orthotopic liver recipients.

Tsubono, T and Todo, S and Jabbour, N and Mizoe, A and Warty, V and Demetris, AJ and Starzl, TE (1996) Indocyanine green elimination test in orthotopic liver recipients. Hepatology, 24 (5). 1165 - 1171. ISSN 0270-9139

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OBJECTIVE: To determine its predictive capability on graft quality and resultant clinical outcome, the indocyanine green (ICG) elimination test was performed by a spectrophotometric method and a noninvasive finger-piece method with 50 orthotopic liver transplantations. BACKGROUND: Early detection of poor-functioning hepatic grafts is one of the most important issues in liver transplantation, but no reliable methods exist. METHODS: The ICG test was performed after 50 orthotopic liver transplantations on postoperative days 1, 3, and 7. Indocyanine green elimination constants (K(ICG)) were measured by both a standard spectrophotometric analysis (K(ICG)-B) and by a finger-piece method (K(ICG)-F). The patients were followed for a minimum of 3 months after transplantation. Results of ICG tests were correlated with various clinical determinations. RESULTS: Twelve of the 50 grafts were lost within three months, of which 7 were related to graft failure. Multivariate analysis using the Cox proportional hazard model revealed that K(ICG) on postoperative day 1 was a better predictor of liver-related graft outcome than any of the conventional liver function tests. Furthermore, K(ICG) values showed significant correlation with the severity of preservation injury, longer intensive care unit (ICU) and hospital stay, prolonged liver dysfunction, and septic complications. Correlation of K(ICG) values by the spectrophotometric method with those by the finger-piece method was highly satisfactory in the grafts that had K(ICG)-B <0.15 min-1 (y = 0.868x -0.011, r = .955). CONCLUSION: The ICG elimination test, conducted spectrophotometrically or optically on the day after liver transplantation, is a reliable indicator of graft quality and subsequent graft outcome early after liver transplantation.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Tsubono, T
Todo, S
Jabbour, N
Mizoe, A
Warty, V
Demetris, AJ
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: November 1996
Date Type: Publication
Journal or Publication Title: Hepatology
Volume: 24
Number: 5
Page Range: 1165 - 1171
DOI or Unique Handle: 10.1002/hep.510240531
Institution: University of Pittsburgh
Refereed: Yes
Uncontrolled Keywords: Adult, Aged, Female, Humans, Indocyanine Green, Liver Circulation, Liver Function Tests, Liver Transplantation, Male, Middle Aged
ISSN: 0270-9139
Funders: NIDDK NIH HHS (R01 DK029961-19), NIDDK NIH HHS (DK-29961)
Other ID: uls-drl:31735062133990, Starzl CV No. 1934
Date Deposited: 08 Apr 2010 17:33
Last Modified: 13 Oct 2017 21:57


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