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A prognostic model for the outcome of liver transplantation in patients with cholestatic liver disease

Ricci, P and Therneau, TM and Malinchoc, M and Benson, JT and Petz, JL and Klintmalm, GB and Crippin, JS and Wiesner, RH and Steers, JL and Rakela, J and Starzl, TE and Rolland Dickson, E (1997) A prognostic model for the outcome of liver transplantation in patients with cholestatic liver disease. Hepatology, 25 (3). 672 - 677. ISSN 0270-9139

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Abstract

We studied the outcome of 436 patients with primary biliary cirrhosis (PBC) or primary sclerosing cholangitis (PSC) who underwent orthotopic liver transplant (OLT) at three major liver transplant centers. Univariate predictors of outcome included age, Karnofsky score, Child's class, Mayo risk score, United Network for Organ Sharing (UNOS) status, nutritional status, serum albumin, serum bilirubin, international normalized ratio, and the presence of ascites, encephalopathy, renal failure (serum creatinine > 2 mg/dL), and edema refractory to diuretics. Using these predictors, we developed a four variable mathematical prognostic model to help the liver transplant physician predict the following: 1) the amount of intraoperative blood loss; 2) the number of days in the intensive care unit (ICU); and 3) severe complications after surgery. The model uses age, renal failure, Child's class, and United Network for Organ Sharing status. This study is the first to model the outcome of liver transplant in patients with a specific etiology of chronic liver disease (PBC or PSC). The model may be used to help select patients for OLT and to plan the timing of their transplantation.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Ricci, P
Therneau, TM
Malinchoc, M
Benson, JT
Petz, JL
Klintmalm, GB
Crippin, JS
Wiesner, RH
Steers, JL
Rakela, J
Starzl, TEtes11@pitt.eduTES11
Rolland Dickson, E
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 17 March 1997
Date Type: Publication
Journal or Publication Title: Hepatology
Volume: 25
Number: 3
Page Range: 672 - 677
DOI or Unique Handle: 10.1002/hep.510250330
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0270-9139
Other ID: uls-drl:31735062134154, Starzl CV No. 1958
Date Deposited: 08 Apr 2010 17:33
Last Modified: 02 Feb 2019 13:56
URI: http://d-scholarship.pitt.edu/id/eprint/5344

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