Murase, N and Ye, Q and Sakamoto, T and Terakura, M and Demetris, AJ and Thomson, AW and Rao, A and Starzl, TE
(1997)
Effect in supralethally irradiated rats of granulocyte colony- stimulating factor and lisofylline on hematopoietic reconstitution by syngeneic bone marrow or whole organ passenger leukocytes.
Transplantation, 63 (12).
1840 - 1843.
ISSN 0041-1337
Abstract
We have previously shown the existence of migratory hematopoietic stem cells in adult solid organs. This study demonstrates that granulocyte colony- stimulating factor (G-CSF) and lisofylline, a phosphatidic acid inhibitor that suppresses hematopoiesis-inhibiting cytokines, can enhance the engraftment of organ-based hematopoietic stem cells. When syngeneic heart grafts or liver nonparenchymal cells were transplanted into lethally irradiated (9.5 Gy) Lewis rats, complete hematopoietic reconstitution and animal survival were significantly improved by treating the recipient with G- CSF or, to a lesser extent, with lisofylline. Pretreatment of hepatic nonparenchymal cell donors with G-CSF, but not lisofylline, also resulted in striking improvement of recipient survival which was associated with an augmented subpopulation of donor stem cells. The results suggest that these drugs can be used to enhance the chimerism that we postulate to be the basis of organ allograft acceptance.
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| Item Type: |
Article
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| Status: |
Published |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Murase, N | | | | | Ye, Q | | | | | Sakamoto, T | | | | | Terakura, M | | | | | Demetris, AJ | | | | | Thomson, AW | | | | | Rao, A | | | | | Starzl, TE | tes11@pitt.edu | TES11 | |
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| Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
| Date: |
27 June 1997 |
| Date Type: |
Publication |
| Journal or Publication Title: |
Transplantation |
| Volume: |
63 |
| Number: |
12 |
| Page Range: |
1840 - 1843 |
| DOI or Unique Handle: |
10.1097/00007890-199706270-00024 |
| Institution: |
University of Pittsburgh |
| Refereed: |
Yes |
| ISSN: |
0041-1337 |
| Other ID: |
uls-drl:31735062134246, Starzl CV No. 1967 |
| Date Deposited: |
08 Apr 2010 17:33 |
| Last Modified: |
29 Jan 2019 15:55 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/5353 |
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