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Lazaroid U-74500A for warm ischemia and reperfusion injury of the canine small intestine

Tanaka, H and Zhu, Y and Zhang, S and Ishizaki, N and Maeng Bong Jin, and Azuma, T and Lee, R and Starzl, TE and Todo, S (1997) Lazaroid U-74500A for warm ischemia and reperfusion injury of the canine small intestine. Journal of the American College of Surgeons, 184 (4). 389 - 396. ISSN 1072-7515

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BACKGROUND: Although lazaroids have been shown to protect various organs from ischemia/reperfusion injury, results obtained in the small intestine have been conflicting. STUDY DESIGN: The canine small intestine was made totally ischemic for 2 hours by occluding the superior mesenteric artery and the superior mesenteric vein with interruption of the mesenteric collateral vessels. A lazaroid compound, U74500A, or a citrate vehicle was given intravenously to each of the six animals for 30 minutes before intestinal ischemia. Intestinal tissue blood flow, lipid peroxidation, neutrophil infiltration, adenine nucleotides and their catabolites, and histologic changes after reperfusion were determined. RESULTS: Lazaroid treatment attenuated decline of the mucosal and serosal blood flow after reperfusion. Accumulation of lipid peroxidation products and neutrophils in mucosal tissues was markedly inhibited by the treatment. Postischemic energy resynthesis was also augmented by lazaroid. Morphologically, mucosal architectures were better preserved with lazaroid treatment after reperfusion, and recovered to normal by postoperative day 3 in the treated group and by post-operative day 7 in control animals. CONCLUSIONS: Lazaroids protect the canine small intestine from ischemia/reperfusion injury by inhibiting lipid peroxidation and neutrophil infiltration. Dogs are tolerant of 2-hour normothermic complete intestinal ischemia.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Tanaka, H
Zhu, Y
Zhang, S
Ishizaki, N
Maeng Bong Jin,
Azuma, T
Lee, R
Starzl, TEtes11@pitt.eduTES11
Todo, S
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 3 May 1997
Date Type: Publication
Journal or Publication Title: Journal of the American College of Surgeons
Volume: 184
Number: 4
Page Range: 389 - 396
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 1072-7515
Other ID: uls-drl:31735062127000, Starzl CV No. 1978
Date Deposited: 08 Apr 2010 17:33
Last Modified: 02 Aug 2020 10:59


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