Bueno, J and Green, M and Kocoshis, S and Furukawa, H and Abu-Elmagd, K and Yunis, E and Irish, W and Todo, S and Reyes, J and Starzl, TE
(1997)
Cytomegalovirus infection after intestinal transplantation in children.
Clinical Infectious Diseases, 25 (5).
1078 - 1083.
ISSN 1058-4838
Abstract
Sixteen episodes of cytomegalovirus (CMV) disease occurred in 10 of 41 children undergoing intestinal transplantation from 1990 to 1995. Stratification of CMV disease by donor (D)/recipient (R) serological status was as follows: 3 of 8, D+/R-; 3 of 9, D+/R+; 4 of 9, D-/R+; and 0 of 15, D- /R-. Treatment resulted in resolution of CMV disease in 93.3% of episodes. No deaths attributable to CMV disease occurred in this series. CMV in D+/R- children resulted in more extensive and persistent disease. However, patient and graft survival rates were similar in the different D/R subgroups and between children with and without CMV disease. Cumulative dose of steroid boluses (relative risk [RR], 1.59; 95% confidence interval [CI], 1.14-2.21) and history of steroid recycles (RR, 2.72; 95% CI, 1.21-6.13) were associated with CMV disease. These results suggest that although CMV-associated morbidity in pediatric intestinal transplant recipients was substantial, it was not associated with an increased rate of mortality or graft loss, even among high-risk D+/R- patients.
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| Item Type: |
Article
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| Status: |
Published |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Bueno, J | | | | | Green, M | greenm@pitt.edu | GREENM | | | Kocoshis, S | | | | | Furukawa, H | | | | | Abu-Elmagd, K | | | | | Yunis, E | | | | | Irish, W | | | | | Todo, S | | | | | Reyes, J | | | | | Starzl, TE | tes11@pitt.edu | TES11 | |
|
| Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
| Date: |
1 January 1997 |
| Date Type: |
Publication |
| Journal or Publication Title: |
Clinical Infectious Diseases |
| Volume: |
25 |
| Number: |
5 |
| Page Range: |
1078 - 1083 |
| DOI or Unique Handle: |
10.1086/516113 |
| Institution: |
University of Pittsburgh |
| Refereed: |
Yes |
| ISSN: |
1058-4838 |
| Other ID: |
uls-drl:31735062127042, Starzl CV No. 1982 |
| Date Deposited: |
08 Apr 2010 17:33 |
| Last Modified: |
02 Feb 2019 13:56 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/5368 |
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