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Cytomegalovirus infection after intestinal transplantation in children

Bueno, J and Green, M and Kocoshis, S and Furukawa, H and Abu-Elmagd, K and Yunis, E and Irish, W and Todo, S and Reyes, J and Starzl, TE (1997) Cytomegalovirus infection after intestinal transplantation in children. Clinical Infectious Diseases, 25 (5). 1078 - 1083. ISSN 1058-4838

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Sixteen episodes of cytomegalovirus (CMV) disease occurred in 10 of 41 children undergoing intestinal transplantation from 1990 to 1995. Stratification of CMV disease by donor (D)/recipient (R) serological status was as follows: 3 of 8, D+/R-; 3 of 9, D+/R+; 4 of 9, D-/R+; and 0 of 15, D- /R-. Treatment resulted in resolution of CMV disease in 93.3% of episodes. No deaths attributable to CMV disease occurred in this series. CMV in D+/R- children resulted in more extensive and persistent disease. However, patient and graft survival rates were similar in the different D/R subgroups and between children with and without CMV disease. Cumulative dose of steroid boluses (relative risk [RR], 1.59; 95% confidence interval [CI], 1.14-2.21) and history of steroid recycles (RR, 2.72; 95% CI, 1.21-6.13) were associated with CMV disease. These results suggest that although CMV-associated morbidity in pediatric intestinal transplant recipients was substantial, it was not associated with an increased rate of mortality or graft loss, even among high-risk D+/R- patients.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Bueno, J
Green, Mgreenm@pitt.eduGREENM
Kocoshis, S
Furukawa, H
Abu-Elmagd, K
Yunis, E
Irish, W
Todo, S
Reyes, J
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1997
Date Type: Publication
Journal or Publication Title: Clinical Infectious Diseases
Volume: 25
Number: 5
Page Range: 1078 - 1083
DOI or Unique Handle: 10.1086/516113
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 1058-4838
Other ID: uls-drl:31735062127042, Starzl CV No. 1982
Date Deposited: 08 Apr 2010 17:33
Last Modified: 02 Feb 2019 13:56


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