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Crystallization and preliminary crystallographic data for the augmenter of liver regeneration

Rose, JP and Wu, CK and Francavilla, A and Prelich, JG and Iacobellis, A and Hagiya, M and Rao, AS and Starzl, TE and Wang, BC (1997) Crystallization and preliminary crystallographic data for the augmenter of liver regeneration. Acta Crystallographica Section D: Biological Crystallography, 53 (3). 331 - 334. ISSN 0907-4449

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Abstract

A new cellular growth factor termed augmenter of liver regeneration (ALR) has been crystallized. ALR has been shown to have a proliferative effect on liver cells while at the same time producing an immunosuppressive effect on liver-resident natural killer cells and liver-resident mononuclear leukocytes. In addition, ALR appears to play an important role in the synthesis and stabilization of mitochondrial gene transcripts inactively regenerating cells. ALR crystals diffract to beyond 2 Å resolution and belong to space group P2 1 2 1 2, with a = 125.1, b = 108.1 and c = 38.5 Å. Based on four molecules per asymmetric unit, the Matthews coefficient is calculated to be 2.16 Å 3 Da -1 which corresponds to a solvent content of 43%.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Rose, JP
Wu, CK
Francavilla, A
Prelich, JG
Iacobellis, A
Hagiya, M
Rao, AS
Starzl, TEtes11@pitt.eduTES11
Wang, BC
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1997
Date Type: Publication
Journal or Publication Title: Acta Crystallographica Section D: Biological Crystallography
Volume: 53
Number: 3
Page Range: 331 - 334
DOI or Unique Handle: 10.1107/s0907444996014084
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0907-4449
Other ID: uls-drl:31735062127372, Starzl CV No. 2016
Date Deposited: 08 Apr 2010 17:34
Last Modified: 17 Oct 2017 17:55
URI: http://d-scholarship.pitt.edu/id/eprint/5402

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