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Amplification of simian retroviral sequences from human recipients of baboon liver transplants

Allan, JS and Broussard, SR and Michaels, MG and Starzl, TE and Leighton, KL and Whitehead, EM and Comuzzie, AG and Lanford, RE and Leland, MM and Switzer, WM and Heneine, W (1998) Amplification of simian retroviral sequences from human recipients of baboon liver transplants. AIDS Research and Human Retroviruses, 14 (10). 821 - 824. ISSN 0889-2229

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Abstract

Investigations into the use of baboons as organ donors for human transplant recipients, a procedure called xenotransplantation, have raised the specter of transmitting baboon viruses to humans and possibly establishing new human infectious diseases. Retrospective analysis of tissues from two human transplant recipients with end-stage hepatic disease who died 70 and 27 days after the transplantation of baboon livers revealed the presence of two simian retroviruses of baboon origin, simian foamy virus (SFV) and baboon endogenous virus (BaEV), in multiple tissue compartments. The presence of baboon mitochondrial DNA was also detected in these same tissues, suggesting that xenogeneic 'passenger leukocytes' harboring latent or active viral infections had migrated from the xenografts to distant sites wi thin the human recipients. The persistence of SFV and BaEV in human recipients throughout the posttransplant period underscores the potential infectious risks associated with xenotransplantation.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Allan, JS
Broussard, SR
Michaels, MG
Starzl, TEtes11@pitt.eduTES11
Leighton, KL
Whitehead, EM
Comuzzie, AG
Lanford, RE
Leland, MM
Switzer, WM
Heneine, W
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 July 1998
Date Type: Publication
Journal or Publication Title: AIDS Research and Human Retroviruses
Volume: 14
Number: 10
Page Range: 821 - 824
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0889-2229
Other ID: uls-drl:31735062127661, Starzl CV No. 2045
Date Deposited: 08 Apr 2010 17:34
Last Modified: 13 Oct 2017 20:55
URI: http://d-scholarship.pitt.edu/id/eprint/5431

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